EMSY and GET3

Data Source:
BioGRID (two hybrid)

		EMSY	GET3
Description		EMSY transcriptional repressor, BRCA2 interacting	guided entry of tail-anchored proteins factor 3, ATPase
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GO Annotations	Cellular Component	Nucleoplasm	Nucleoplasm Nucleolus Cytoplasm Endoplasmic Reticulum Membrane GET Complex Extracellular Exosome
	Molecular Function	Protein Binding Identical Protein Binding	Protein Binding ATP Binding Arsenite Transmembrane Transporter Activity ATPase Activity Metal Ion Binding
	Biological Process	DNA Repair Chromatin Organization Regulation Of Transcription, DNA-templated	Posttranslational Protein Targeting To Endoplasmic Reticulum Membrane Arsenite Transport IRE1-mediated Unfolded Protein Response Tail-anchored Membrane Protein Insertion Into ER Membrane
Pathways			Insertion of tail-anchored proteins into the endoplasmic reticulum membrane
Drugs			ATP
Diseases
GWAS		Allergic rhinitis ( 31361310) Asthma ( 31361310 31959851 29273806) Asthma (adult onset) ( 31036433) Asthma (age of onset) ( 31036433) Asthma (childhood onset) ( 31036433) Eczema ( 31361310) Eosinophil counts ( 29403010)
Interacting Genes		14 interacting genes: AIDA AKT1 BRCA2 CBX1 CLVS2 DDIT3 DISC1 GET3 H3-4 LIX1 PSMA1 ZMYND11 ZNF131 ZNF646	41 interacting genes: AGR2 APLN ASPH CACNA1A CAMLG CREB3L4 EMSY FAM209A FKBP7 GET4 GOLM1 GPX7 GPX8 HILPDA IGFBP6 KCNE4 KCNE5 LDLRAD4 PDIA6 PEX14 PFDN1 PGRMC1 PGRMC2 PRB3 PRR4 RHEX SEC61A1 SEC61B SMIM19 SPP1 STATH STX5 SYPL2 TK1 TMEM154 TMEM51 TMX1 TTR VAMP2 VWC2 WFDC3
Entrez ID		56946	439
HPRD ID		10544	03555
Ensembl ID		ENSG00000158636	ENSG00000198356
Uniprot IDs		Q7Z589	O43681
PDB IDs		1UTU 1UZ3 2FMM	6SO5
Enriched GO Terms of Interacting Partners?
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