GET3 and LDLRAD4

Data Source:
BioGRID (two hybrid)

		GET3	LDLRAD4
Description		guided entry of tail-anchored proteins factor 3, ATPase	low density lipoprotein receptor class A domain containing 4
Image			No pdb structure
GO Annotations	Cellular Component	Nucleoplasm Nucleolus Cytoplasm Endoplasmic Reticulum Membrane GET Complex Extracellular Exosome	Golgi Membrane Integral Component Of Membrane Early Endosome Membrane Intracellular Membrane-bounded Organelle
	Molecular Function	Protein Binding ATP Binding Arsenite Transmembrane Transporter Activity ATPase Activity Metal Ion Binding	R-SMAD Binding
	Biological Process	Posttranslational Protein Targeting To Endoplasmic Reticulum Membrane Arsenite Transport IRE1-mediated Unfolded Protein Response Tail-anchored Membrane Protein Insertion Into ER Membrane	Negative Regulation Of Epithelial To Mesenchymal Transition Negative Regulation Of SMAD Protein Complex Assembly Negative Regulation Of Cell Migration Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of Pathway-restricted SMAD Protein Phosphorylation
Pathways		Insertion of tail-anchored proteins into the endoplasmic reticulum membrane
Drugs		ATP
Diseases
GWAS			Adverse response to drug ( 30420678) Depressive symptom improvement ( 30468137) Gut microbiota (functional units) ( 27694959) Macular thickness ( 30535121) Plateletcrit ( 32888494)
Interacting Genes		41 interacting genes: AGR2 APLN ASPH CACNA1A CAMLG CREB3L4 EMSY FAM209A FKBP7 GET4 GOLM1 GPX7 GPX8 HILPDA IGFBP6 KCNE4 KCNE5 LDLRAD4 PDIA6 PEX14 PFDN1 PGRMC1 PGRMC2 PRB3 PRR4 RHEX SEC61A1 SEC61B SMIM19 SPP1 STATH STX5 SYPL2 TK1 TMEM154 TMEM51 TMX1 TTR VAMP2 VWC2 WFDC3	3 interacting genes: GET3 SGTA ZDHHC22
Entrez ID		439	753
HPRD ID		03555	07358
Ensembl ID		ENSG00000198356	ENSG00000168675
Uniprot IDs		O43681	A8K6A9 O15165
PDB IDs		6SO5
Enriched GO Terms of Interacting Partners?
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