GET3 and TMEM51

Data Source:
BioGRID (two hybrid)

		GET3	TMEM51
Description		guided entry of tail-anchored proteins factor 3, ATPase	transmembrane protein 51
Image			No pdb structure
GO Annotations	Cellular Component	Nucleoplasm Nucleolus Cytoplasm Endoplasmic Reticulum Membrane GET Complex Extracellular Exosome	Cellular_component Integral Component Of Membrane
	Molecular Function	Protein Binding ATP Binding Arsenite Transmembrane Transporter Activity ATPase Activity Metal Ion Binding	Molecular_function Protein Binding
	Biological Process	Posttranslational Protein Targeting To Endoplasmic Reticulum Membrane Arsenite Transport IRE1-mediated Unfolded Protein Response Tail-anchored Membrane Protein Insertion Into ER Membrane	Biological_process
Pathways		Insertion of tail-anchored proteins into the endoplasmic reticulum membrane
Drugs		ATP
Diseases
GWAS			Acute ischemic stroke x type 2 diabetes interaction ( 32541925) Cocaine use disorder ( 31490055) Cocaine use disorder x non-traditional parental care interaction ( 31490055)
Interacting Genes		41 interacting genes: AGR2 APLN ASPH CACNA1A CAMLG CREB3L4 EMSY FAM209A FKBP7 GET4 GOLM1 GPX7 GPX8 HILPDA IGFBP6 KCNE4 KCNE5 LDLRAD4 PDIA6 PEX14 PFDN1 PGRMC1 PGRMC2 PRB3 PRR4 RHEX SEC61A1 SEC61B SMIM19 SPP1 STATH STX5 SYPL2 TK1 TMEM154 TMEM51 TMX1 TTR VAMP2 VWC2 WFDC3	36 interacting genes: AQP6 BCL2L13 C14orf180 C4orf3 CCDC167 CCL4L2 CLCA4 CREB3 CYB5R3 CYP4F2 EBP GET3 LMNA MRPL12 NINJ2 PLP2 PTPN5 REEP4 RTP2 SEC61G SFT2D2 SFXN3 SMAGP SMIM1 STRIT1 TMEM107 TMEM14A TMEM14B TMEM242 TMEM254 TMIE TMX2 TSNARE1 UBE2J1 VAMP4 VTI1B
Entrez ID		439	55092
HPRD ID		03555	07651
Ensembl ID		ENSG00000198356	ENSG00000171729
Uniprot IDs		O43681	A0A024QZ97 Q9BSA0 Q9NW97
PDB IDs		6SO5
Enriched GO Terms of Interacting Partners?
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