GET3 and EMSY

Data Source:
BioGRID (two hybrid)

		GET3	EMSY
Description		guided entry of tail-anchored proteins factor 3, ATPase	EMSY transcriptional repressor, BRCA2 interacting
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GO Annotations	Cellular Component	Nucleoplasm Nucleolus Cytoplasm Endoplasmic Reticulum Membrane GET Complex Extracellular Exosome	Nucleoplasm
	Molecular Function	Protein Binding ATP Binding Arsenite Transmembrane Transporter Activity ATPase Activity Metal Ion Binding	Protein Binding Identical Protein Binding
	Biological Process	Posttranslational Protein Targeting To Endoplasmic Reticulum Membrane Arsenite Transport IRE1-mediated Unfolded Protein Response Tail-anchored Membrane Protein Insertion Into ER Membrane	DNA Repair Chromatin Organization Regulation Of Transcription, DNA-templated
Pathways		Insertion of tail-anchored proteins into the endoplasmic reticulum membrane
Drugs		ATP
Diseases
GWAS			Allergic rhinitis ( 31361310) Asthma ( 31361310 31959851 29273806) Asthma (adult onset) ( 31036433) Asthma (age of onset) ( 31036433) Asthma (childhood onset) ( 31036433) Eczema ( 31361310) Eosinophil counts ( 29403010)
Interacting Genes		41 interacting genes: AGR2 APLN ASPH CACNA1A CAMLG CREB3L4 EMSY FAM209A FKBP7 GET4 GOLM1 GPX7 GPX8 HILPDA IGFBP6 KCNE4 KCNE5 LDLRAD4 PDIA6 PEX14 PFDN1 PGRMC1 PGRMC2 PRB3 PRR4 RHEX SEC61A1 SEC61B SMIM19 SPP1 STATH STX5 SYPL2 TK1 TMEM154 TMEM51 TMX1 TTR VAMP2 VWC2 WFDC3	14 interacting genes: AIDA AKT1 BRCA2 CBX1 CLVS2 DDIT3 DISC1 GET3 H3-4 LIX1 PSMA1 ZMYND11 ZNF131 ZNF646
Entrez ID		439	56946
HPRD ID		03555	10544
Ensembl ID		ENSG00000198356	ENSG00000158636
Uniprot IDs		O43681	Q7Z589
PDB IDs		6SO5	1UTU 1UZ3 2FMM
Enriched GO Terms of Interacting Partners?
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