GET3 and TMX1

Data Source:
BioGRID (two hybrid)

		GET3	TMX1
Description		guided entry of tail-anchored proteins factor 3, ATPase	thioredoxin related transmembrane protein 1
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GO Annotations	Cellular Component	Nucleoplasm Nucleolus Cytoplasm Endoplasmic Reticulum Membrane GET Complex Extracellular Exosome	Endoplasmic Reticulum Membrane Integral Component Of Membrane
	Molecular Function	Protein Binding ATP Binding Arsenite Transmembrane Transporter Activity ATPase Activity Metal Ion Binding	Protein Binding Disulfide Oxidoreductase Activity
	Biological Process	Posttranslational Protein Targeting To Endoplasmic Reticulum Membrane Arsenite Transport IRE1-mediated Unfolded Protein Response Tail-anchored Membrane Protein Insertion Into ER Membrane	Response To Endoplasmic Reticulum Stress
Pathways		Insertion of tail-anchored proteins into the endoplasmic reticulum membrane
Drugs		ATP
Diseases
GWAS			Cancer ( 29299148) Nonsyndromic cleft lip with or without cleft palate ( 28087736) Response to cyclophosphamide in systemic lupus erythematosus with lupus nephritis ( 26980576)
Interacting Genes		41 interacting genes: AGR2 APLN ASPH CACNA1A CAMLG CREB3L4 EMSY FAM209A FKBP7 GET4 GOLM1 GPX7 GPX8 HILPDA IGFBP6 KCNE4 KCNE5 LDLRAD4 PDIA6 PEX14 PFDN1 PGRMC1 PGRMC2 PRB3 PRR4 RHEX SEC61A1 SEC61B SMIM19 SPP1 STATH STX5 SYPL2 TK1 TMEM154 TMEM51 TMX1 TTR VAMP2 VWC2 WFDC3	12 interacting genes: BCL2L2 CCR1 CDC42 FAS FKBP8 GET3 GIMAP1 GIMAP5 LHFPL5 PMP22 SPI1 SULT2A1
Entrez ID		439	81542
HPRD ID		03555	15590
Ensembl ID		ENSG00000198356	ENSG00000139921
Uniprot IDs		O43681	Q9H3N1
PDB IDs		6SO5	1X5E
Enriched GO Terms of Interacting Partners?
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