TTC19 and NME4

Data Source:
BioGRID (two hybrid)

		TTC19	NME4
Description		tetratricopeptide repeat domain 19	NME/NM23 nucleoside diphosphate kinase 4
Image		No pdb structure
GO Annotations	Cellular Component	Mitochondrion Mitochondrial Inner Membrane Centrosome Midbody Respirasome	Mitochondrion Mitochondrial Inner Membrane Mitochondrial Intermembrane Space Mitochondrial Matrix
	Molecular Function	Protein Binding	Nucleoside Diphosphate Kinase Activity Protein Binding ATP Binding Metal Ion Binding Cardiolipin Binding
	Biological Process	Mitotic Cytokinesis Mitochondrial Respiratory Chain Complex III Assembly	Nucleoside Diphosphate Phosphorylation GTP Biosynthetic Process UTP Biosynthetic Process CTP Biosynthetic Process Lipid Transport Nucleoside Metabolic Process Nucleobase-containing Small Molecule Interconversion
Pathways			Interconversion of nucleotide di- and triphosphates
Drugs
Diseases		Mitochondrial respiratory chain deficiencies (MRCD), including: Mitochondrial complex I deficiency (MT-C1D); Complex II deficiency (MT-C2D); Complex III deficiency (MT-C3D); Complex IV deficiency (MT-C4D); Complex V deficiency (MT-ATPSD); Leigh syndrome (LS); Kearns-Sayre Syndrome (KSS); LCHD deficiency (LCHD); Leber Hereditary Optic Neuropathy (LHON); Myoclonic Epilepsy and Ragged-Red Fiber Disease (MERRF); NARP; MELAS; ACAD9 deficiency; HADH deficiency; HIBCH deficiency; GRACILE syndrome
GWAS			Body mass index ( 26426971) Red blood cell traits ( 23446634)
Interacting Genes		44 interacting genes: AGXT APRT ATXN1 C20orf85 CCDC33 CHMP4A COA6 CYSLTR2 DMRT3 EIF4ENIF1 FAM136A FAM217B FH FTO GORASP2 GPANK1 HOXD12 HPS6 IHO1 L3MBTL3 LDB2 MLN MXRA8 NAB2 NME4 POU6F2 PRR35 RBP1 REL RUSC1 RXFP3 SH2D4A SHISA6 SLC22A18AS SMG9 SPRED1 TBX2 TCAP UBA1 UPF3B USP20 USP54 WASHC1 ZNF688	40 interacting genes: ABI2 ARMC7 ATPAF2 C14orf119 C1orf109 CABP2 CABP5 CCDC102B CCDC57 CDKN2D CFAP206 CIB1 CIB3 CIDEB CLNK DTX2 HDAC7 HSF2BP LMO4 LSM8 MKRN3 MLH1 NME1 NME1-NME2 NME7 NUTF2 NXF1 POLR1C PSMB1 SOCS3 SPG21 SUV39H2 TNS4 TRAPPC2 TRAPPC2B TRIP13 TSSK3 TTC19 UBL5 ZBTB16
Entrez ID		54902	4833
HPRD ID		07899	03489
Ensembl ID		ENSG00000011295	ENSG00000103202
Uniprot IDs		A0A024RD83 Q6DKK2	A0A087WVT9 O00746
PDB IDs			1EHW
Enriched GO Terms of Interacting Partners?
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