NME4 and LSM8

Data Source:
BioGRID (two hybrid)

		NME4	LSM8
Description		NME/NM23 nucleoside diphosphate kinase 4	LSM8 homolog, U6 small nuclear RNA associated
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GO Annotations	Cellular Component	Mitochondrion Mitochondrial Inner Membrane Mitochondrial Intermembrane Space Mitochondrial Matrix	Nucleus Nucleoplasm U6 SnRNP U4/U6 X U5 Tri-snRNP Complex U2-type Precatalytic Spliceosome Precatalytic Spliceosome Lsm2-8 Complex
	Molecular Function	Nucleoside Diphosphate Kinase Activity Protein Binding ATP Binding Metal Ion Binding Cardiolipin Binding	RNA Binding Protein Binding U6 SnRNA Binding
	Biological Process	Nucleoside Diphosphate Phosphorylation GTP Biosynthetic Process UTP Biosynthetic Process CTP Biosynthetic Process Lipid Transport Nucleoside Metabolic Process Nucleobase-containing Small Molecule Interconversion	MRNA Splicing, Via Spliceosome RNA Metabolic Process
Pathways		Interconversion of nucleotide di- and triphosphates	mRNA Splicing - Major Pathway
Drugs
Diseases
GWAS		Body mass index ( 26426971) Red blood cell traits ( 23446634)	Anti-thyroglobulin (TgAb) levels in Hashimoto's thyroiditis ( 30926877) Anti-thyroid peroxidase (TPOAb) and anti-thyroglobulin (TgAb) levels in Hashimoto's thyroiditis ( 30926877) Glaucoma (primary open-angle) ( 29891935) Intraocular pressure ( 29617998) Plasma anti-thyroid peroxidase levels ( 29678681) Positive urgency ( 30718321) Response to methotrexate in juvenile idiopathic arthritis ( 24709693) Triglyceride levels ( 30108155)
Interacting Genes		40 interacting genes: ABI2 ARMC7 ATPAF2 C14orf119 C1orf109 CABP2 CABP5 CCDC102B CCDC57 CDKN2D CFAP206 CIB1 CIB3 CIDEB CLNK DTX2 HDAC7 HSF2BP LMO4 LSM8 MKRN3 MLH1 NME1 NME1-NME2 NME7 NUTF2 NXF1 POLR1C PSMB1 SOCS3 SPG21 SUV39H2 TNS4 TRAPPC2 TRAPPC2B TRIP13 TSSK3 TTC19 UBL5 ZBTB16	49 interacting genes: ARNT BCKDK COL23A1 DBF4 DCP1A DCP1B DPAGT1 ECHDC2 EFTUD2 EXOSC10 EXOSC6 FERMT3 GMPPA GTF2I HSPA9 IFNLR1 IGHMBP2 ISOC2 ITSN2 KCTD3 LSM2 LSM3 LSM5 LSM6 LSM7 MAPK8IP2 MGA MINDY1 MPRIP MRPL48 MTHFR NAGK NME4 PDCD2 PGD PHF11 RBM5 RPL24 RSC1A1 RSL24D1 SEPTIN10 SEPTIN5 SMU1 SNRNP200 SNRPB SNRPD1 TALDO1 THUMPD3 UPF1
Entrez ID		4833	51691
HPRD ID		03489	06288
Ensembl ID		ENSG00000103202	ENSG00000128534
Uniprot IDs		A0A087WVT9 O00746	A4D0W0 O95777
PDB IDs		1EHW	3JCR 5O9Z 6AH0 6AHD 6QW6 6QX9
Enriched GO Terms of Interacting Partners?
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