SHC3 and ASPG

Data Source:
BioGRID (two hybrid)

		SHC3	ASPG
Description		SHC adaptor protein 3	asparaginase
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Cellular_component Cytosol Plasma Membrane	Cytosol
	Molecular Function	Phosphotyrosine Residue Binding Protein Binding Protein Kinase Binding Receptor Tyrosine Kinase Binding	1-alkyl-2-acetylglycerophosphocholine Esterase Activity Asparaginase Activity Lysophospholipase Activity Protein Binding Transferase Activity, Transferring Acyl Groups Other Than Amino-acyl Groups Phosphatidyl Phospholipase B Activity
	Biological Process	MAPK Cascade Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Epidermal Growth Factor Receptor Signaling Pathway Ras Protein Signal Transduction Axon Guidance Central Nervous System Development	Cellular Amino Acid Biosynthetic Process Lipid Catabolic Process
Pathways		Signalling to RAS Signalling to RAS RAF/MAP kinase cascade RET signaling	Aspartate and asparagine metabolism
Drugs			Procaine
Diseases
GWAS		Logical memory (delayed recall) in Alzheimer's disease dementia ( 29274321) Pelvic organ prolapse (moderate/severe) ( 26545240) Response to statins (LDL cholesterol change) ( 22331829) Superior parietal cortex volume ( 31530798) Systolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858)	Blood metabolite levels ( 24816252) Body mass index ( 26426971) Plasma free amino acid levels (adjusted for one other PFAA) ( 30659259) Plasma free amino acid levels (adjusted for twenty other PFAAs) ( 30659259) Plasma free asparagine levels ( 30659259) Refractive error ( 32231278) Schizophrenia ( 29483656) Serum metabolite concentrations in chronic kidney disease ( 29545352)
Interacting Genes		58 interacting genes: ALK ANKRD10 APP AR ARHGAP32 ASPG AXL BMF CCNC CDCA4 CEACAM6 COPS6 CT55 DOK3 EGFR ERBB2 ERBB3 ERBB4 FLT4 FTO GAB1 GOLGA2 GOLGA6L9 GRB2 KIT KRT31 KRT33B KRT34 KRT35 KRT39 KRT40 KRT86 MET NTRK1 NTRK2 PMF1 PNMA1 PPP1R16B PRKAR1B PSMD8 REL RET SH3GL3 SMYD3 STX11 TRAF1 TRAF2 TRIM35 TRIM54 TSC1 UBAP2 USHBP1 USP54 VPS28 WWOX YPEL3 YPEL5 ZMYND12	12 interacting genes: C20orf85 CEACAM6 DMRT3 GSDMD MYOZ3 RTP5 SGK1 SHC3 TEKT3 TMEM115 USP2 VPS25
Entrez ID		53358	374569
HPRD ID		12005	19180
Ensembl ID		ENSG00000148082	ENSG00000166183
Uniprot IDs		Q92529	Q86U10
PDB IDs
Enriched GO Terms of Interacting Partners?
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