SHC3 and CDCA4

Data Source:
BioGRID (two hybrid)

		SHC3	CDCA4
Description		SHC adaptor protein 3	cell division cycle associated 4
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Cellular_component Cytosol Plasma Membrane	Nucleus Nucleoplasm Cytosol Plasma Membrane
	Molecular Function	Phosphotyrosine Residue Binding Protein Binding Protein Kinase Binding Receptor Tyrosine Kinase Binding	Protein Binding Transcription Regulator Activity
	Biological Process	MAPK Cascade Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Epidermal Growth Factor Receptor Signaling Pathway Ras Protein Signal Transduction Axon Guidance Central Nervous System Development	Chromatin-mediated Maintenance Of Transcription
Pathways		Signalling to RAS Signalling to RAS RAF/MAP kinase cascade RET signaling
Drugs
Diseases
GWAS		Logical memory (delayed recall) in Alzheimer's disease dementia ( 29274321) Pelvic organ prolapse (moderate/severe) ( 26545240) Response to statins (LDL cholesterol change) ( 22331829) Superior parietal cortex volume ( 31530798) Systolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858)	Cerebrospinal fluid t-tau levels ( 29274321) Cerebrospinal fluid t-tau levels in normal cognition ( 29274321) Leukocyte telomere length ( 32109421)
Interacting Genes		58 interacting genes: ALK ANKRD10 APP AR ARHGAP32 ASPG AXL BMF CCNC CDCA4 CEACAM6 COPS6 CT55 DOK3 EGFR ERBB2 ERBB3 ERBB4 FLT4 FTO GAB1 GOLGA2 GOLGA6L9 GRB2 KIT KRT31 KRT33B KRT34 KRT35 KRT39 KRT40 KRT86 MET NTRK1 NTRK2 PMF1 PNMA1 PPP1R16B PRKAR1B PSMD8 REL RET SH3GL3 SMYD3 STX11 TRAF1 TRAF2 TRIM35 TRIM54 TSC1 UBAP2 USHBP1 USP54 VPS28 WWOX YPEL3 YPEL5 ZMYND12	25 interacting genes: BFSP2 C1orf109 DOK5 ENKD1 FAM222B FARS2 FNDC11 KAT2B KDM1A KLHL42 MKRN3 PARD6B PRMT6 SEPHS1 SHC3 SUOX SUPT7L SUV39H1 SUV39H2 TCAP TRIM28 TXN2 XPO1 YPEL3 ZNF451
Entrez ID		53358	55038
HPRD ID		12005	13015
Ensembl ID		ENSG00000148082	ENSG00000170779
Uniprot IDs		Q92529	A0A024R6P3 Q9BXL8
PDB IDs
Enriched GO Terms of Interacting Partners?
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