SHC3 and YPEL5

Data Source:
BioGRID (two hybrid)

		SHC3	YPEL5
Description		SHC adaptor protein 3	yippee like 5
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Cellular_component Cytosol Plasma Membrane	Ubiquitin Ligase Complex Extracellular Region Nucleus Centrosome Midbody Mitotic Spindle Pole Tertiary Granule Lumen Ficolin-1-rich Granule Lumen
	Molecular Function	Phosphotyrosine Residue Binding Protein Binding Protein Kinase Binding Receptor Tyrosine Kinase Binding	Protein Binding Metal Ion Binding
	Biological Process	MAPK Cascade Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Epidermal Growth Factor Receptor Signaling Pathway Ras Protein Signal Transduction Axon Guidance Central Nervous System Development	Cell Population Proliferation Neutrophil Degranulation
Pathways		Signalling to RAS Signalling to RAS RAF/MAP kinase cascade RET signaling	Neutrophil degranulation
Drugs
Diseases
GWAS		Logical memory (delayed recall) in Alzheimer's disease dementia ( 29274321) Pelvic organ prolapse (moderate/severe) ( 26545240) Response to statins (LDL cholesterol change) ( 22331829) Superior parietal cortex volume ( 31530798) Systolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858)	Celiac disease and Rheumatoid arthritis ( 26546613) Triglyceride levels x short total sleep time interaction (2df test) ( 31719535)
Interacting Genes		58 interacting genes: ALK ANKRD10 APP AR ARHGAP32 ASPG AXL BMF CCNC CDCA4 CEACAM6 COPS6 CT55 DOK3 EGFR ERBB2 ERBB3 ERBB4 FLT4 FTO GAB1 GOLGA2 GOLGA6L9 GRB2 KIT KRT31 KRT33B KRT34 KRT35 KRT39 KRT40 KRT86 MET NTRK1 NTRK2 PMF1 PNMA1 PPP1R16B PRKAR1B PSMD8 REL RET SH3GL3 SMYD3 STX11 TRAF1 TRAF2 TRIM35 TRIM54 TSC1 UBAP2 USHBP1 USP54 VPS28 WWOX YPEL3 YPEL5 ZMYND12	13 interacting genes: CTDSP1 DDIT4L FBXO7 GSC2 MAEA MAPKBP1 PFDN5 PLAGL2 PSMA1 RANBP9 SHC3 TRAF5 ZNF655
Entrez ID		53358	51646
HPRD ID		12005	18312
Ensembl ID		ENSG00000148082	ENSG00000119801
Uniprot IDs		Q92529	P62699
PDB IDs
Enriched GO Terms of Interacting Partners?
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