SHC3 and ANKRD10

Data Source:
BioGRID (two hybrid)

		SHC3	ANKRD10
Description		SHC adaptor protein 3	ankyrin repeat domain 10
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Cellular_component Cytosol Plasma Membrane
	Molecular Function	Phosphotyrosine Residue Binding Protein Binding Protein Kinase Binding Receptor Tyrosine Kinase Binding	Protein Binding
	Biological Process	MAPK Cascade Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Epidermal Growth Factor Receptor Signaling Pathway Ras Protein Signal Transduction Axon Guidance Central Nervous System Development
Pathways		Signalling to RAS Signalling to RAS RAF/MAP kinase cascade RET signaling
Drugs
Diseases
GWAS		Logical memory (delayed recall) in Alzheimer's disease dementia ( 29274321) Pelvic organ prolapse (moderate/severe) ( 26545240) Response to statins (LDL cholesterol change) ( 22331829) Superior parietal cortex volume ( 31530798) Systolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858)	Apolipoprotein A1 levels ( 32203549) Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223) Refractive error ( 32231278)
Interacting Genes		58 interacting genes: ALK ANKRD10 APP AR ARHGAP32 ASPG AXL BMF CCNC CDCA4 CEACAM6 COPS6 CT55 DOK3 EGFR ERBB2 ERBB3 ERBB4 FLT4 FTO GAB1 GOLGA2 GOLGA6L9 GRB2 KIT KRT31 KRT33B KRT34 KRT35 KRT39 KRT40 KRT86 MET NTRK1 NTRK2 PMF1 PNMA1 PPP1R16B PRKAR1B PSMD8 REL RET SH3GL3 SMYD3 STX11 TRAF1 TRAF2 TRIM35 TRIM54 TSC1 UBAP2 USHBP1 USP54 VPS28 WWOX YPEL3 YPEL5 ZMYND12	16 interacting genes: APPBP2 ATG9A CSTF2 FAM222B FOXI1 GIGYF1 OTX1 PEF1 PITX1 POGZ POU6F2 SHC3 SNRPC TLX3 TRIP13 ZIC1
Entrez ID		53358	55608
HPRD ID		12005	12455
Ensembl ID		ENSG00000148082	ENSG00000088448
Uniprot IDs		Q92529	A0A024RE01 Q9NXR5
PDB IDs
Enriched GO Terms of Interacting Partners?
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