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SHC3 and NTRK1
Data Source:
HPRD
(in vivo)
SHC3
NTRK1
Description
SHC adaptor protein 3
neurotrophic receptor tyrosine kinase 1
Image
No pdb structure
GO Annotations
Cellular Component
Cellular_component
Cytosol
Plasma Membrane
Golgi Membrane
Early Endosome
Late Endosome
Plasma Membrane
Integral Component Of Plasma Membrane
Cell Surface
Endosome Membrane
Axon
Dendrite
Early Endosome Membrane
Late Endosome Membrane
Protein-containing Complex
Neuronal Cell Body
Receptor Complex
Recycling Endosome Membrane
Molecular Function
Phosphotyrosine Residue Binding
Protein Binding
Protein Kinase Binding
Receptor Tyrosine Kinase Binding
Protein Tyrosine Kinase Activity
Transmembrane Receptor Protein Tyrosine Kinase Activity
GPI-linked Ephrin Receptor Activity
Neurotrophin Receptor Activity
Neurotrophin P75 Receptor Binding
Protein Binding
ATP Binding
Nerve Growth Factor Receptor Activity
Kinase Binding
Identical Protein Binding
Protein Homodimerization Activity
Neurotrophin Binding
Nerve Growth Factor Binding
Biological Process
MAPK Cascade
Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway
Epidermal Growth Factor Receptor Signaling Pathway
Ras Protein Signal Transduction
Axon Guidance
Central Nervous System Development
Activation Of MAPKK Activity
Positive Regulation Of Protein Phosphorylation
Protein Phosphorylation
Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway
Multicellular Organism Development
Axon Guidance
Aging
Learning Or Memory
Circadian Rhythm
Negative Regulation Of Cell Population Proliferation
Response To Radiation
Programmed Cell Death Involved In Cell Development
Positive Regulation Of Neuron Projection Development
Positive Regulation Of Phosphatidylinositol 3-kinase Signaling
Peptidyl-tyrosine Phosphorylation
Olfactory Nerve Development
B Cell Differentiation
Response To Nutrient Levels
Positive Regulation Of Kinase Activity
Peptidyl-tyrosine Autophosphorylation
Nerve Growth Factor Signaling Pathway
Mechanoreceptor Differentiation
Response To Drug
Negative Regulation Of Apoptotic Process
Positive Regulation Of Programmed Cell Death
Positive Regulation Of MAPK Cascade
Negative Regulation Of Neuron Apoptotic Process
Positive Regulation Of GTPase Activity
Positive Regulation Of Ras Protein Signal Transduction
Protein Autophosphorylation
Neurotrophin TRK Receptor Signaling Pathway
Ephrin Receptor Signaling Pathway
Phosphatidylinositol-mediated Signaling
Sympathetic Nervous System Development
Response To Axon Injury
Detection Of Temperature Stimulus Involved In Sensory Perception Of Pain
Detection Of Mechanical Stimulus Involved In Sensory Perception Of Pain
Positive Regulation Of NF-kappaB Transcription Factor Activity
Response To Hydrostatic Pressure
Response To Electrical Stimulus
Regulation Of Protein Kinase B Signaling
Positive Regulation Of Synapse Assembly
Positive Regulation Of Synaptic Transmission, Glutamatergic
Sertoli Cell Development
Axonogenesis Involved In Innervation
Behavioral Response To Formalin Induced Pain
Positive Regulation Of ERK1 And ERK2 Cascade
Cellular Response To Nicotine
Cellular Response To Amyloid-beta
Cellular Response To Nerve Growth Factor Stimulus
Pathways
Signalling to RAS
Signalling to RAS
RAF/MAP kinase cascade
RET signaling
PLC-gamma1 signalling
Signalling to RAS
ARMS-mediated activation
ARMS-mediated activation
Retrograde neurotrophin signalling
Retrograde neurotrophin signalling
NGF-independant TRKA activation
TRKA activation by NGF
TRKA activation by NGF
Signalling to p38 via RIT and RIN
PI3K/AKT activation
PI3K/AKT activation
Signalling to STAT3
Drugs
Amitriptyline
Imatinib
Regorafenib
Entrectinib
Fostamatinib
Cenegermin
Larotrectinib
Pralsetinib
Diseases
Neuroblastoma
Thyroid cancer
GWAS
Logical memory (delayed recall) in Alzheimer's disease dementia (
29274321
)
Pelvic organ prolapse (moderate/severe) (
26545240
)
Response to statins (LDL cholesterol change) (
22331829
)
Superior parietal cortex volume (
31530798
)
Systolic blood pressure x smoking status (ever vs never) interaction (2df test) (
29455858
)
Red cell distribution width (
32888494
)
Interacting Genes
58 interacting genes:
ALK
ANKRD10
APP
AR
ARHGAP32
ASPG
AXL
BMF
CCNC
CDCA4
CEACAM6
COPS6
CT55
DOK3
EGFR
ERBB2
ERBB3
ERBB4
FLT4
FTO
GAB1
GOLGA2
GOLGA6L9
GRB2
KIT
KRT31
KRT33B
KRT34
KRT35
KRT39
KRT40
KRT86
MET
NTRK1
NTRK2
PMF1
PNMA1
PPP1R16B
PRKAR1B
PSMD8
REL
RET
SH3GL3
SMYD3
STX11
TRAF1
TRAF2
TRIM35
TRIM54
TSC1
UBAP2
USHBP1
USP54
VPS28
WWOX
YPEL3
YPEL5
ZMYND12
40 interacting genes:
ABL1
ARHGAP32
CAV1
CRK
DNAJA3
DYNLL1
ERBB2
FRS2
FRS3
GIPC1
GRB2
IRS1
IRS2
KIDINS220
MAPK3
MATK
NEDD4L
NGF
NGFR
NTF3
PIK3R1
PLCG1
PTPN1
PTPN11
PTPRR
RAP1A
RASA1
RASGRF1
RUSC1
SH2B1
SH2B2
SHC1
SHC2
SHC3
SORT1
SQSTM1
TPTE
TRAF4
TRAF6
UBB
Entrez ID
53358
4914
HPRD ID
12005
01869
Ensembl ID
ENSG00000148082
ENSG00000198400
Uniprot IDs
Q92529
P04629
X5DR71
PDB IDs
1HE7
1SHC
1WWA
1WWW
2IFG
2N90
4AOJ
4CRP
4F0I
4GT5
4PMM
4PMP
4PMS
4PMT
4YNE
4YPS
5H3Q
5I8A
5JFS
5JFV
5JFW
5JFX
5KMI
5KMJ
5KMK
5KML
5KMM
5KMN
5KMO
5KVT
5WR7
6D1Y
6D1Z
6D20
6D22
6DKB
6DKG
6DKI
6DKW
6IQN
6J5L
6NPT
6NSP
6NSS
6PL1
6PL2
6PL3
6PL4
6PMA
6PMB
6PMC
6PME
Enriched GO Terms of Interacting Partners
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Tagcloud (Intersection)
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