STX8 and SLC22A2

Data Source:
BioGRID (protein complementation assay)

		STX8	SLC22A2
Description		syntaxin 8	solute carrier family 22 member 2
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Lysosomal Membrane Endosome Early Endosome Late Endosome Endoplasmic Reticulum Trans-Golgi Network Cytosol Integral Component Of Plasma Membrane Endomembrane System Integral Component Of Membrane SNARE Complex Late Endosome Membrane Vesicle Phagocytic Vesicle Perinuclear Region Of Cytoplasm Recycling Endosome	Plasma Membrane Integral Component Of Plasma Membrane Membrane Apical Plasma Membrane Extracellular Exosome Presynapse
	Molecular Function	SNARE Binding SNAP Receptor Activity Protein Binding Chloride Channel Inhibitor Activity Syntaxin Binding Ubiquitin Protein Ligase Binding	Amine Transmembrane Transporter Activity Neurotransmitter Transmembrane Transporter Activity Monoamine Transmembrane Transporter Activity Organic Cation Transmembrane Transporter Activity L-amino Acid Transmembrane Transporter Activity Pyrimidine Nucleoside Transmembrane Transporter Activity Choline Transmembrane Transporter Activity Efflux Transmembrane Transporter Activity Toxin Transmembrane Transporter Activity Xenobiotic Transmembrane Transporter Activity L-arginine Transmembrane Transporter Activity
	Biological Process	Intracellular Protein Transport Vesicle Fusion Endosome To Lysosome Transport Early Endosome To Late Endosome Transport Vesicle Docking Cellular Response To Interferon-gamma Regulation Of Protein Localization To Plasma Membrane	Neurotransmitter Transport Drug Transmembrane Transport Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Neurotransmitter Secretion Body Fluid Secretion Positive Regulation Of Gene Expression Organic Cation Transport Amine Transport Choline Transport Neurotransmitter Biosynthetic Process Xenobiotic Transport Serotonin Uptake Histamine Uptake Norepinephrine Uptake Pyrimidine-containing Compound Transmembrane Transport Amino Acid Import Across Plasma Membrane Dopamine Uptake L-arginine Import Across Plasma Membrane Export Across Plasma Membrane Transport Across Blood-brain Barrier Toxin Transport L-alpha-amino Acid Transmembrane Transport Xenobiotic Transport Across Blood-brain Barrier
Pathways			Neurotransmitter clearance Norepinephrine Neurotransmitter Release Cycle Abacavir transmembrane transport Na+/Cl- dependent neurotransmitter transporters Organic cation transport
Drugs
Diseases
GWAS		Blood protein levels ( 30072576) Borderline personality disorder ( 28632202) Brain morphology (MOSTest) ( 32665545) Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223) HDL cholesterol change in response to fenofibrate in statin-treated type 2 diabetes ( 28736931) Obstructive sleep apnea trait (apnea hypopnea index) ( 29077507)	Body mass index ( 26426971 25673413) Body mass index (age>50) ( 26426971) Body mass index x sex x age interaction (4df test) ( 26426971) Chronic kidney disease ( 31152163 20383146) Creatinine levels ( 31015462 29403010 20383145) Estimated glomerular filtration rate ( 31152163 31015462 31451708 30604766) Estimated glomerular filtration rate in diabetes ( 31451708) Estimated glomerular filtration rate in non-diabetics ( 31451708) Familial squamous cell lung carcinoma ( 29924316) Glomerular filtration rate ( 27588450 29403010) Glomerular filtration rate (creatinine) ( 28452372 26831199) Glomerular filtration rate in non diabetics (creatinine) ( 26831199) Kidney stones ( 31729369) Lipoprotein (a) levels ( 26377243) Lipoprotein (a) levels in coronary artery disease (percutaneous coronary intervention) ( 31186284) Prostate cancer ( 26034056) Serum metabolite levels ( 23093944) Waist circumference ( 26785701)
Interacting Genes		83 interacting genes: ACVR1 AMIGO1 AQP2 ASGR2 BCL2L13 BIK BSND CALM1 CD300E CD79A CERS4 CLDN9 CLN8 COPA CPLX4 CREB3 CREB3L1 DHRS9 EBP ERGIC3 FAM174A FAM209A FFAR2 FKBP7 FNDC9 GJA8 GJB1 GORAB GPR151 GPR152 GPR42 GPX8 JAGN1 JSRP1 KCNMB1 LMNA MCEE MCL1 MFF MGST2 MGST3 MMGT1 MS4A3 MTERF3 NAPA NAPG NCR3LG1 NDUFAF1 NDUFAF2 NSF PEX12 PSCA RETREG3 RNASEK SAR1A SCN3B SGPL1 SLC10A6 SLC18A1 SLC22A2 SSMEM1 STAR STMN4 STX1A STX2 STX4 STX5 STX7 TGFBR1 TMED8 TMEM14B TMEM179B TMEM205 TMEM237 TMEM86B TMPPE TMPRSS2 TSPAN12 VAMP5 VPS11 VPS18 VTI1B WDR91	45 interacting genes: AGO3 CCL2 CD63 CD9 CLPTM1 CST9L CYB5R3 DPM2 EEF1G ETV5 EXT2 FAIM2 FIS1 FXYD2 FZD5 GTF2B HNRNPH3 HRCT1 HYAL3 ITM2C KRTCAP2 LAPTM4A LAPTM4B LAPTM5 LSM4 NCOA3 PDIA6 PDZK1IP1 POU2AF1 PRPF8 RPN2 SERP1 SLC40A1 SLC47A2 SPCS1 STX8 SUMO2 TMEM134 TMEM147 TMEM161A TMEM176B TMEM41B TMX2 TREX1 VKORC1
Entrez ID		9482	6582
HPRD ID		05012	04008
Ensembl ID		ENSG00000170310	ENSG00000112499
Uniprot IDs		Q9UNK0	O15244
PDB IDs
Enriched GO Terms of Interacting Partners?
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