STX8 and SLC18A1

Data Source:
BioGRID (two hybrid)

		STX8	SLC18A1
Description		syntaxin 8	solute carrier family 18 member A1
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Lysosomal Membrane Endosome Early Endosome Late Endosome Endoplasmic Reticulum Trans-Golgi Network Cytosol Integral Component Of Plasma Membrane Endomembrane System Integral Component Of Membrane SNARE Complex Late Endosome Membrane Vesicle Phagocytic Vesicle Perinuclear Region Of Cytoplasm Recycling Endosome	Endoplasmic Reticulum Membrane Integral Component Of Membrane Synaptic Vesicle Membrane Terminal Bouton Clathrin-sculpted Monoamine Transport Vesicle Membrane
	Molecular Function	SNARE Binding SNAP Receptor Activity Protein Binding Chloride Channel Inhibitor Activity Syntaxin Binding Ubiquitin Protein Ligase Binding	Serotonin:sodium Symporter Activity Monoamine Transmembrane Transporter Activity Transmembrane Transporter Activity Xenobiotic Transmembrane Transporter Activity
	Biological Process	Intracellular Protein Transport Vesicle Fusion Endosome To Lysosome Transport Early Endosome To Late Endosome Transport Vesicle Docking Cellular Response To Interferon-gamma Regulation Of Protein Localization To Plasma Membrane	Aminergic Neurotransmitter Loading Into Synaptic Vesicle Monoamine Transport Xenobiotic Transport Serotonin Uptake Transmembrane Transport
Pathways			Na+/Cl- dependent neurotransmitter transporters
Drugs			Reserpine Norepinephrine Ephedra sinica root MMDA Metamfetamine
Diseases
GWAS		Blood protein levels ( 30072576) Borderline personality disorder ( 28632202) Brain morphology (MOSTest) ( 32665545) Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223) HDL cholesterol change in response to fenofibrate in statin-treated type 2 diabetes ( 28736931) Obstructive sleep apnea trait (apnea hypopnea index) ( 29077507)	Apolipoprotein A1 levels ( 32203549) Cholesterol ( 31902109) Coronary artery disease ( 30104761) Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223) HDL cholesterol levels ( 32203549) Hypertriglyceridemia ( 23505323) Major depressive disorder (broad) ( 20038947) Metabolic syndrome ( 30382898 31589552) Pulse pressure ( 27841878) Susceptibility to persistent hepatitis B virus infection ( 27244555) Systolic blood pressure ( 27841878) Triglyceride levels ( 32203549) Triglycerides ( 18193046 24886709)
Interacting Genes		83 interacting genes: ACVR1 AMIGO1 AQP2 ASGR2 BCL2L13 BIK BSND CALM1 CD300E CD79A CERS4 CLDN9 CLN8 COPA CPLX4 CREB3 CREB3L1 DHRS9 EBP ERGIC3 FAM174A FAM209A FFAR2 FKBP7 FNDC9 GJA8 GJB1 GORAB GPR151 GPR152 GPR42 GPX8 JAGN1 JSRP1 KCNMB1 LMNA MCEE MCL1 MFF MGST2 MGST3 MMGT1 MS4A3 MTERF3 NAPA NAPG NCR3LG1 NDUFAF1 NDUFAF2 NSF PEX12 PSCA RETREG3 RNASEK SAR1A SCN3B SGPL1 SLC10A6 SLC18A1 SLC22A2 SSMEM1 STAR STMN4 STX1A STX2 STX4 STX5 STX7 TGFBR1 TMED8 TMEM14B TMEM179B TMEM205 TMEM237 TMEM86B TMPPE TMPRSS2 TSPAN12 VAMP5 VPS11 VPS18 VTI1B WDR91	60 interacting genes: AGTRAP ANKRD46 APOL2 BRICD5 C2CD2L CCL4 CCL4L2 CNIH1 COL4A5 CTSA CXCL16 CYB561D2 FAM3C FCER1G FXYD3 GIMAP1 GJB2 GPR151 LAT MALL MFSD6 MGAM MIP MS4A1 MS4A13 NEU1 NRM OLFM4 ORMDL1 PEX16 PLP1 PLP2 PMP22 PNLIPRP1 RPRM SLC30A2 SLC30A8 SLC35B4 SLC35G1 SLC38A7 SLC39A2 SMCO4 SMIM1 STX2 STX8 TFRC TMEM120B TMEM128 TMEM14A TMEM14B TMEM203 TMEM218 TMEM239 TMEM42 TMEM60 TMEM65 TMEM86A VAMP5 YIPF4 YIPF6
Entrez ID		9482	6570
HPRD ID		05012	01897
Ensembl ID		ENSG00000170310	ENSG00000036565
Uniprot IDs		Q9UNK0	P54219 Q96GL6
PDB IDs
Enriched GO Terms of Interacting Partners?
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