LSM8 and BCKDK

Data Source:
BioGRID (two hybrid)

		LSM8	BCKDK
Description		LSM8 homolog, U6 small nuclear RNA associated	branched chain keto acid dehydrogenase kinase
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm U6 SnRNP U4/U6 X U5 Tri-snRNP Complex U2-type Precatalytic Spliceosome Precatalytic Spliceosome Lsm2-8 Complex	Mitochondrion Mitochondrial Matrix Mitochondrial Alpha-ketoglutarate Dehydrogenase Complex
	Molecular Function	RNA Binding Protein Binding U6 SnRNA Binding	Protein Serine/threonine Kinase Activity Pyruvate Dehydrogenase (acetyl-transferring) Kinase Activity Protein Binding ATP Binding Kinase Activity [3-methyl-2-oxobutanoate Dehydrogenase (acetyl-transferring)] Kinase Activity
	Biological Process	MRNA Splicing, Via Spliceosome RNA Metabolic Process	Protein Phosphorylation Cellular Amino Acid Catabolic Process Branched-chain Amino Acid Catabolic Process Regulation Of Glucose Metabolic Process Phosphorylation
Pathways		mRNA Splicing - Major Pathway	Branched-chain amino acid catabolism
Drugs			Adenosine 5'-[gamma-thio]triphosphate
Diseases
GWAS		Anti-thyroglobulin (TgAb) levels in Hashimoto's thyroiditis ( 30926877) Anti-thyroid peroxidase (TPOAb) and anti-thyroglobulin (TgAb) levels in Hashimoto's thyroiditis ( 30926877) Glaucoma (primary open-angle) ( 29891935) Intraocular pressure ( 29617998) Plasma anti-thyroid peroxidase levels ( 29678681) Positive urgency ( 30718321) Response to methotrexate in juvenile idiopathic arthritis ( 24709693) Triglyceride levels ( 30108155)	Bipolar disorder ( 31043756) Bipolar I disorder ( 31043756) Parkinson's disease ( 25064009) Systolic blood pressure ( 31928498) Triglyceride levels ( 31928498) Waist circumference ( 31928498)
Interacting Genes		49 interacting genes: ARNT BCKDK COL23A1 DBF4 DCP1A DCP1B DPAGT1 ECHDC2 EFTUD2 EXOSC10 EXOSC6 FERMT3 GMPPA GTF2I HSPA9 IFNLR1 IGHMBP2 ISOC2 ITSN2 KCTD3 LSM2 LSM3 LSM5 LSM6 LSM7 MAPK8IP2 MGA MINDY1 MPRIP MRPL48 MTHFR NAGK NME4 PDCD2 PGD PHF11 RBM5 RPL24 RSC1A1 RSL24D1 SEPTIN10 SEPTIN5 SMU1 SNRNP200 SNRPB SNRPD1 TALDO1 THUMPD3 UPF1	8 interacting genes: APP EPS8 FBXO7 LSM8 NR5A2 SPTA1 STAT3 TRAF4
Entrez ID		51691	10295
HPRD ID		06288	12523
Ensembl ID		ENSG00000128534	ENSG00000103507
Uniprot IDs		A4D0W0 O95777	A0A024QZA9 O14874
PDB IDs		3JCR 5O9Z 6AH0 6AHD 6QW6 6QX9
Enriched GO Terms of Interacting Partners?
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