LSM8 and SMU1

Data Source:
BioGRID (two hybrid)

		LSM8	SMU1
Description		LSM8 homolog, U6 small nuclear RNA associated	SMU1 DNA replication regulator and spliceosomal factor
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GO Annotations	Cellular Component	Nucleus Nucleoplasm U6 SnRNP U4/U6 X U5 Tri-snRNP Complex U2-type Precatalytic Spliceosome Precatalytic Spliceosome Lsm2-8 Complex	Nucleus Cytoplasm Nuclear Speck U2-type Precatalytic Spliceosome Precatalytic Spliceosome
	Molecular Function	RNA Binding Protein Binding U6 SnRNA Binding	Protein Binding
	Biological Process	MRNA Splicing, Via Spliceosome RNA Metabolic Process	Regulation Of Alternative MRNA Splicing, Via Spliceosome MRNA Splicing, Via Spliceosome RNA Splicing Viral Process
Pathways		mRNA Splicing - Major Pathway
Drugs
Diseases
GWAS		Anti-thyroglobulin (TgAb) levels in Hashimoto's thyroiditis ( 30926877) Anti-thyroid peroxidase (TPOAb) and anti-thyroglobulin (TgAb) levels in Hashimoto's thyroiditis ( 30926877) Glaucoma (primary open-angle) ( 29891935) Intraocular pressure ( 29617998) Plasma anti-thyroid peroxidase levels ( 29678681) Positive urgency ( 30718321) Response to methotrexate in juvenile idiopathic arthritis ( 24709693) Triglyceride levels ( 30108155)	Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223)
Interacting Genes		49 interacting genes: ARNT BCKDK COL23A1 DBF4 DCP1A DCP1B DPAGT1 ECHDC2 EFTUD2 EXOSC10 EXOSC6 FERMT3 GMPPA GTF2I HSPA9 IFNLR1 IGHMBP2 ISOC2 ITSN2 KCTD3 LSM2 LSM3 LSM5 LSM6 LSM7 MAPK8IP2 MGA MINDY1 MPRIP MRPL48 MTHFR NAGK NME4 PDCD2 PGD PHF11 RBM5 RPL24 RSC1A1 RSL24D1 SEPTIN10 SEPTIN5 SMU1 SNRNP200 SNRPB SNRPD1 TALDO1 THUMPD3 UPF1	12 interacting genes: CD2BP2 CERT1 H2BC21 IK LSM4 LSM8 MRFAP1 MRFAP1L1 MSS51 RASSF10 TLX3 YBX1
Entrez ID		51691	55234
HPRD ID		06288	11588
Ensembl ID		ENSG00000128534	ENSG00000122692
Uniprot IDs		A4D0W0 O95777	A0MNN4 Q2TAY7
PDB IDs		3JCR 5O9Z 6AH0 6AHD 6QW6 6QX9	5O9Z 6AHD 6Q8F 6Q8I 6Q8J
Enriched GO Terms of Interacting Partners?
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