MSH4 and MLH3

Data Source:
HPRD (in vitro)

		MSH4	MLH3
Description		mutS homolog 4	mutL homolog 3
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Synaptonemal Complex Nucleus Chromosome Recombination Nodule	Synaptonemal Complex Male Germ Cell Nucleus Nucleus Nucleoplasm Chiasma Mismatch Repair Complex
	Molecular Function	DNA Binding Protein Binding ATP Binding DNA-dependent ATPase Activity Mismatched DNA Binding	Chromatin Binding Satellite DNA Binding Protein Binding ATP Binding ATPase Activity Centromeric DNA Binding Mismatched DNA Binding
	Biological Process	Meiotic Mismatch Repair Resolution Of Meiotic Recombination Intermediates Ovarian Follicle Development Homologous Chromosome Pairing At Meiosis Reciprocal Meiotic Recombination Spermatogenesis Female Gamete Generation	Mismatch Repair Synaptonemal Complex Assembly Reciprocal Meiotic Recombination Male Meiotic Nuclear Division Female Meiosis I Protein Localization
Pathways		Meiotic recombination	Meiotic recombination
Drugs
Diseases			Mismatch repair deficiency, including: Hereditary non-polyposis colorectal cancer (HNPCC); Lynch syndrome; Muir-Torre syndrome; Turcot syndrome
GWAS		Attention function in attention deficit hyperactive disorder ( 26174813) Daytime sleep phenotypes ( 27126917) Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223) Serum metabolite levels ( 23093944)	Inflammatory bowel disease ( 23128233) Mood instability ( 29187730) Refractive error ( 32231278)
Interacting Genes		8 interacting genes: DMC1 EIF3F MLH1 MLH3 MSH5 RAD51 RPA1 VBP1	45 interacting genes: AKT1 ALDOB ANP32B AOPEP AR BAAT CCDC180 CDC14B CDK8 CTSV CYLC2 DVL1 FANCC FBP1 FBP2 FRAT2 GALNT12 HEMGN HRAS HSD17B3 IGFBP3 LEF1 MAP2K1 MLH1 MSANTD3 MSH4 NANS PPP2CB PPP3R2 RASA1 SEC61B SFRP2 SMAD1 STX17 TBC1D2 TDRD7 TGFB1 TMEFF1 TMOD1 TRIM55 TRIM63 TSTD2 XPA ZDHHC17 ZNF510
Entrez ID		4438	27030
HPRD ID		03658	05094
Ensembl ID		ENSG00000057468	ENSG00000119684
Uniprot IDs		O15457	Q2M1Z1 Q9UHC1
PDB IDs
Enriched GO Terms of Interacting Partners?
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