MSH4 and MSH5

Data Source:
HPRD (two hybrid, in vitro)

		MSH4	MSH5
Description		mutS homolog 4	mutS homolog 5
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Synaptonemal Complex Nucleus Chromosome Recombination Nodule	Nuclear Chromosome
	Molecular Function	DNA Binding Protein Binding ATP Binding DNA-dependent ATPase Activity Mismatched DNA Binding	Protein Binding ATP Binding DNA-dependent ATPase Activity Mismatched DNA Binding
	Biological Process	Meiotic Mismatch Repair Resolution Of Meiotic Recombination Intermediates Ovarian Follicle Development Homologous Chromosome Pairing At Meiosis Reciprocal Meiotic Recombination Spermatogenesis Female Gamete Generation	Meiotic Mismatch Repair Reciprocal Meiotic Recombination
Pathways		Meiotic recombination	Meiotic recombination
Drugs
Diseases
GWAS		Attention function in attention deficit hyperactive disorder ( 26174813) Daytime sleep phenotypes ( 27126917) Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223) Serum metabolite levels ( 23093944)	Asthma ( 31619474) Asthma (childhood onset) ( 31619474) Asthma and major depressive disorder ( 31619474) Autism spectrum disorder or schizophrenia ( 28540026) Blond vs. brown/black hair color ( 30531825) Blood protein levels ( 28240269) Clozapine-induced agranulocytosis/granulocytopenia in treatment-resistant schizophrenia ( 26876947) Cutaneous lupus erythematosus ( 25827949) Inflammatory bowel disease ( 28067908) Lung cancer ( 18978787) Medication use (anilides) ( 31015401) Menopause (age at onset) ( 26414677) Pulse pressure ( 27618448) Systemic lupus erythematosus ( 26316170) Systolic blood pressure ( 27618448) Takayasu arteritis ( 25604533) Ulcerative colitis ( 24837172 28067908)
Interacting Genes		8 interacting genes: DMC1 EIF3F MLH1 MLH3 MSH5 RAD51 RPA1 VBP1	2 interacting genes: MSH4 TRIM54
Entrez ID		4438	4439
HPRD ID		03658	04544
Ensembl ID		ENSG00000057468	ENSG00000204410
Uniprot IDs		O15457	A0A024RCM1 A0A024RCV6 O43196
PDB IDs
Enriched GO Terms of Interacting Partners?
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