MLH3 and TMEFF1

Data Source:
BioGRID (two hybrid)

		MLH3	TMEFF1
Description		mutL homolog 3	transmembrane protein with EGF like and two follistatin like domains 1
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Synaptonemal Complex Male Germ Cell Nucleus Nucleus Nucleoplasm Chiasma Mismatch Repair Complex	Basement Membrane Plasma Membrane Integral Component Of Membrane
	Molecular Function	Chromatin Binding Satellite DNA Binding Protein Binding ATP Binding ATPase Activity Centromeric DNA Binding Mismatched DNA Binding	Signaling Receptor Binding
	Biological Process	Mismatch Repair Synaptonemal Complex Assembly Reciprocal Meiotic Recombination Male Meiotic Nuclear Division Female Meiosis I Protein Localization	Motor Neuron Axon Guidance Animal Organ Morphogenesis Tissue Development Dendrite Development
Pathways		Meiotic recombination
Drugs
Diseases		Mismatch repair deficiency, including: Hereditary non-polyposis colorectal cancer (HNPCC); Lynch syndrome; Muir-Torre syndrome; Turcot syndrome
GWAS		Inflammatory bowel disease ( 23128233) Mood instability ( 29187730) Refractive error ( 32231278)	Familial squamous cell lung carcinoma ( 29924316)
Interacting Genes		45 interacting genes: AKT1 ALDOB ANP32B AOPEP AR BAAT CCDC180 CDC14B CDK8 CTSV CYLC2 DVL1 FANCC FBP1 FBP2 FRAT2 GALNT12 HEMGN HRAS HSD17B3 IGFBP3 LEF1 MAP2K1 MLH1 MSANTD3 MSH4 NANS PPP2CB PPP3R2 RASA1 SEC61B SFRP2 SMAD1 STX17 TBC1D2 TDRD7 TGFB1 TMEFF1 TMOD1 TRIM55 TRIM63 TSTD2 XPA ZDHHC17 ZNF510	9 interacting genes: APC BUB1 CCR1 CDKN2A DLC1 FLCN MLH3 PTEN PTPRJ
Entrez ID		27030	8577
HPRD ID		05094	04570
Ensembl ID		ENSG00000119684	ENSG00000241697
Uniprot IDs		Q2M1Z1 Q9UHC1	Q8IYR6
PDB IDs
Enriched GO Terms of Interacting Partners?
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