MLH3 and ALDOB

Data Source:
BioGRID (two hybrid)

		MLH3	ALDOB
Description		mutL homolog 3	aldolase, fructose-bisphosphate B
Image		No pdb structure
GO Annotations	Cellular Component	Synaptonemal Complex Male Germ Cell Nucleus Nucleus Nucleoplasm Chiasma Mismatch Repair Complex	Microtubule Organizing Center Cytosol Centriolar Satellite Extracellular Exosome
	Molecular Function	Chromatin Binding Satellite DNA Binding Protein Binding ATP Binding ATPase Activity Centromeric DNA Binding Mismatched DNA Binding	Fructose-bisphosphate Aldolase Activity Protein Binding Cytoskeletal Protein Binding Identical Protein Binding ATPase Binding Fructose-1-phosphate Aldolase Activity Fructose Binding
	Biological Process	Mismatch Repair Synaptonemal Complex Assembly Reciprocal Meiotic Recombination Male Meiotic Nuclear Division Female Meiosis I Protein Localization	Fructose Metabolic Process Gluconeogenesis Glycolytic Process NADH Oxidation Fructose 1,6-bisphosphate Metabolic Process Positive Regulation Of ATPase Activity Canonical Glycolysis Fructose Catabolic Process To Hydroxyacetone Phosphate And Glyceraldehyde-3-phosphate Vacuolar Proton-transporting V-type ATPase Complex Assembly
Pathways		Meiotic recombination	Hereditary fructose intolerance Glycolysis Gluconeogenesis Fructose catabolism
Drugs			1,6-Fructose Diphosphate (Linear Form) sn-glycerol 3-phosphate Dihydroxyacetone phosphate
Diseases		Mismatch repair deficiency, including: Hereditary non-polyposis colorectal cancer (HNPCC); Lynch syndrome; Muir-Torre syndrome; Turcot syndrome	Hereditary fructose intolerance; Fructosemia
GWAS		Inflammatory bowel disease ( 23128233) Mood instability ( 29187730) Refractive error ( 32231278)	Age-related cataracts ( 25352737) Liver enzyme levels (alkaline phosphatase) ( 22001757) Serum alkaline phosphatase levels ( 29403010)
Interacting Genes		45 interacting genes: AKT1 ALDOB ANP32B AOPEP AR BAAT CCDC180 CDC14B CDK8 CTSV CYLC2 DVL1 FANCC FBP1 FBP2 FRAT2 GALNT12 HEMGN HRAS HSD17B3 IGFBP3 LEF1 MAP2K1 MLH1 MSANTD3 MSH4 NANS PPP2CB PPP3R2 RASA1 SEC61B SFRP2 SMAD1 STX17 TBC1D2 TDRD7 TGFB1 TMEFF1 TMOD1 TRIM55 TRIM63 TSTD2 XPA ZDHHC17 ZNF510	22 interacting genes: AGXT2 ALDOA APP ATP6V1E1 BMPR1A BUB1 CDKN2A CTNNA1 DCC FLCN HIVEP1 HSPA8 MAP2K4 MCC MLH1 MLH3 MUC20 NRAS SMAD4 SRC STK11 TXN2
Entrez ID		27030	229
HPRD ID		05094	01972
Ensembl ID		ENSG00000119684	ENSG00000136872
Uniprot IDs		Q2M1Z1 Q9UHC1	A0A024R145 P05062
PDB IDs			1QO5 1XDL 1XDM
Enriched GO Terms of Interacting Partners?
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