MLH3 and TDRD7

Data Source:
BioGRID (two hybrid)

		MLH3	TDRD7
Description		mutL homolog 3	tudor domain containing 7
Image		No pdb structure
GO Annotations	Cellular Component	Synaptonemal Complex Male Germ Cell Nucleus Nucleus Nucleoplasm Chiasma Mismatch Repair Complex	Cytoplasm Mitochondrial Matrix Chromatoid Body Ribonucleoprotein Granule
	Molecular Function	Chromatin Binding Satellite DNA Binding Protein Binding ATP Binding ATPase Activity Centromeric DNA Binding Mismatched DNA Binding	MRNA Binding Protein Binding Protein N-terminus Binding
	Biological Process	Mismatch Repair Synaptonemal Complex Assembly Reciprocal Meiotic Recombination Male Meiotic Nuclear Division Female Meiosis I Protein Localization	Lens Morphogenesis In Camera-type Eye Spermatogenesis Posttranscriptional Regulation Of Gene Expression Lens Fiber Cell Differentiation
Pathways		Meiotic recombination
Drugs
Diseases		Mismatch repair deficiency, including: Hereditary non-polyposis colorectal cancer (HNPCC); Lynch syndrome; Muir-Torre syndrome; Turcot syndrome
GWAS		Inflammatory bowel disease ( 23128233) Mood instability ( 29187730) Refractive error ( 32231278)	Bisphosphonate-associated atypical femoral fracture ( 31006051) Refractive error ( 32231278) Waist-hip ratio ( 28552196)
Interacting Genes		45 interacting genes: AKT1 ALDOB ANP32B AOPEP AR BAAT CCDC180 CDC14B CDK8 CTSV CYLC2 DVL1 FANCC FBP1 FBP2 FRAT2 GALNT12 HEMGN HRAS HSD17B3 IGFBP3 LEF1 MAP2K1 MLH1 MSANTD3 MSH4 NANS PPP2CB PPP3R2 RASA1 SEC61B SFRP2 SMAD1 STX17 TBC1D2 TDRD7 TGFB1 TMEFF1 TMOD1 TRIM55 TRIM63 TSTD2 XPA ZDHHC17 ZNF510	20 interacting genes: ATXN2 BUB1 CABLES1 CCND1 CDK17 CDKN2A CTNNA1 DCC DLC1 FRAT1 GABPB1 MAGEA8 MLH1 MLH3 MSH2 MUTYH NRAS ODC1 STK11 TACC1
Entrez ID		27030	23424
HPRD ID		05094	11626
Ensembl ID		ENSG00000119684	ENSG00000196116
Uniprot IDs		Q2M1Z1 Q9UHC1	Q8NHU6
PDB IDs			3RCO
Enriched GO Terms of Interacting Partners?
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