MLH3 and IGFBP3

Data Source:
BioGRID (two hybrid)

		MLH3	IGFBP3
Description		mutL homolog 3	insulin like growth factor binding protein 3
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Synaptonemal Complex Male Germ Cell Nucleus Nucleus Nucleoplasm Chiasma Mismatch Repair Complex	Extracellular Region Extracellular Space Nucleus Endoplasmic Reticulum Lumen Insulin-like Growth Factor Binding Protein Complex Insulin-like Growth Factor Ternary Complex
	Molecular Function	Chromatin Binding Satellite DNA Binding Protein Binding ATP Binding ATPase Activity Centromeric DNA Binding Mismatched DNA Binding	Fibronectin Binding Protein Binding Insulin-like Growth Factor Binding Protein Tyrosine Phosphatase Activator Activity Insulin-like Growth Factor I Binding Insulin-like Growth Factor II Binding Metal Ion Binding
	Biological Process	Mismatch Repair Synaptonemal Complex Assembly Reciprocal Meiotic Recombination Male Meiotic Nuclear Division Female Meiosis I Protein Localization	Regulation Of Cell Growth Osteoblast Differentiation Negative Regulation Of Protein Phosphorylation Protein Phosphorylation Apoptotic Process Negative Regulation Of Cell Population Proliferation Negative Regulation Of Signal Transduction Regulation Of Glucose Metabolic Process Negative Regulation Of Smooth Muscle Cell Migration Regulation Of Apoptotic Process Positive Regulation Of Apoptotic Process Positive Regulation Of MAPK Cascade Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway Positive Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway Regulation Of Phosphoprotein Phosphatase Activity Post-translational Protein Modification Cellular Protein Metabolic Process Type B Pancreatic Cell Proliferation Positive Regulation Of Myoblast Differentiation Negative Regulation Of Smooth Muscle Cell Proliferation
Pathways		Meiotic recombination	Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) TP53 Regulates Transcription of Death Receptors and Ligands Post-translational protein phosphorylation
Drugs			Alitretinoin Mecasermin
Diseases		Mismatch repair deficiency, including: Hereditary non-polyposis colorectal cancer (HNPCC); Lynch syndrome; Muir-Torre syndrome; Turcot syndrome
GWAS		Inflammatory bowel disease ( 23128233) Mood instability ( 29187730) Refractive error ( 32231278)	Birth weight ( 31043758) Blood pressure traits (multi-trait analysis) ( 28498854) Blood protein levels ( 30072576 29875488 23696881) Cataracts (operation) ( 31816047) Diastolic blood pressure ( 27841878 28498854 30578418) FEV1 ( 30804560) Height ( 25282103 31562340) Hypospadias ( 25108383) Insulin-like growth factors ( 21216879) Lung function (FVC) ( 30804560) Macular thickness ( 30535121) Major depressive disorder ( 23377640) Male-pattern baldness ( 27182965) Molybdenum levels ( 26025379) Night sleep phenotypes ( 27126917) Offspring birth weight ( 31043758) Poor prognosis in Crohn's disease ( 28067912) Pulse pressure ( 26390057 28135244 27841878 29403010 28739976 27618448 28498854 30487518) QRS duration ( 27577874 21076409) Rosacea symptom severity ( 29771307) Sitting height ratio ( 25865494) Subjective response to lithium treatment in bipolar disorder ( 26503763) Systolic blood pressure ( 27841878 27618447 27618448) Tonsillectomy ( 27182965 28928442) Venous thromboembolism ( 26888256)
Interacting Genes		45 interacting genes: AKT1 ALDOB ANP32B AOPEP AR BAAT CCDC180 CDC14B CDK8 CTSV CYLC2 DVL1 FANCC FBP1 FBP2 FRAT2 GALNT12 HEMGN HRAS HSD17B3 IGFBP3 LEF1 MAP2K1 MLH1 MSANTD3 MSH4 NANS PPP2CB PPP3R2 RASA1 SEC61B SFRP2 SMAD1 STX17 TBC1D2 TDRD7 TGFB1 TMEFF1 TMOD1 TRIM55 TRIM63 TSTD2 XPA ZDHHC17 ZNF510	38 interacting genes: ADAM12 AURKA BMPR1A BUB1 CAV1 CCND1 CD44 COL1A1 CSNK2A1 CTSD CTSG CTSL F2 FBXW7 FN1 GPI GTF3C1 IGF1 IGF1R IGF2 IGFALS KLK3 KLKB1 KPNB1 KRAS LTBP1 MLH3 MMP1 MMP2 MMP3 PAPPA2 PLG POLA2 PPARG RAD54B RXRA STK11 TF
Entrez ID		27030	3486
HPRD ID		05094	00899
Ensembl ID		ENSG00000119684	ENSG00000146674
Uniprot IDs		Q2M1Z1 Q9UHC1	B3KPF0 P17936
PDB IDs
Enriched GO Terms of Interacting Partners?
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