KPNA5 and BRMS1

Data Source:
HPRD (two hybrid)

		KPNA5	BRMS1
Description		karyopherin subunit alpha 5	BRMS1 transcriptional repressor and anoikis regulator
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytosol	Nucleus Nucleoplasm Cytoplasm Sin3-type Complex
	Molecular Function	Protein Binding Nuclear Localization Sequence Binding Nuclear Import Signal Receptor Activity	Protein Binding Histone Deacetylase Binding NF-kappaB Binding
	Biological Process	NLS-bearing Protein Import Into Nucleus Modulation By Virus Of Host Cellular Process	Negative Regulation Of Transcription By RNA Polymerase II Apoptotic Process Histone Deacetylation Negative Regulation Of NF-kappaB Transcription Factor Activity Regulation Of Apoptotic Process Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Protein Deacetylation Positive Regulation Of Anoikis
Pathways		ISG15 antiviral mechanism NS1 Mediated Effects on Host Pathways	HDACs deacetylate histones Potential therapeutics for SARS
Drugs
Diseases
GWAS		Early cardiac repolarization ( 31600170) Telomere length ( 21460395)	Bipolar disorder ( 21926972 31043756)
Interacting Genes		28 interacting genes: ANP32A ANP32B ARNT BRMS1 CDKN1B DCPS EPAS1 FAM214B FBXO7 HIF1A HNRNPC IL32 KAT5 LMNB1 MLH1 NMNAT1 NRF1 NUP50 POLR3C POU6F2 RAD52 RBBP4 SPOP SPOPL TSEN54 TWIST1 WT1 ZNF326	49 interacting genes: ANGPTL4 APP ARID4A BEX2 BRMS1L CEP70 CSNK2A1 CYTOR DIRAS3 DNAJB1 DNAJB6 E2F1 EEF1A1 EP300 GOLGB1 HDAC1 HDAC2 HDAC3 HDAC4 HDAC5 HDAC6 HSP90AA1 HSPA4 IL13RA2 ING1 KLK9 KPNA5 LRIF1 LYPD3 MCRS1 MRC2 NMI PFDN5 PSMC3IP RBBP4 RBBP7 RBP1 RELA SAP30 SIN3A SMARCE1 SMTN SNAI1 SNX6 SPOP SUDS3 TAF1 THRSP UBE2D1
Entrez ID		3841	25855
HPRD ID		05179	05879
Ensembl ID		ENSG00000196911	ENSG00000174744
Uniprot IDs		O15131	G5E9I4 Q9HCU9
PDB IDs		4U2X	2XUS 4AUV
Enriched GO Terms of Interacting Partners?
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