BRMS1 and PSMC3IP

Data Source:
BioGRID (two hybrid)

		BRMS1	PSMC3IP
Description		BRMS1 transcriptional repressor and anoikis regulator	PSMC3 interacting protein
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Sin3-type Complex	Nucleoplasm
	Molecular Function	Protein Binding Histone Deacetylase Binding NF-kappaB Binding	DNA Binding Nuclear Receptor Coactivator Activity
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Apoptotic Process Histone Deacetylation Negative Regulation Of NF-kappaB Transcription Factor Activity Regulation Of Apoptotic Process Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Protein Deacetylation Positive Regulation Of Anoikis	Reciprocal Meiotic Recombination Positive Regulation Of Transcription, DNA-templated
Pathways		HDACs deacetylate histones Potential therapeutics for SARS	Meiotic recombination
Drugs
Diseases
GWAS		Bipolar disorder ( 21926972 31043756)	Colorectal or endometrial cancer ( 26621817) White blood cell count ( 32888494)
Interacting Genes		49 interacting genes: ANGPTL4 APP ARID4A BEX2 BRMS1L CEP70 CSNK2A1 CYTOR DIRAS3 DNAJB1 DNAJB6 E2F1 EEF1A1 EP300 GOLGB1 HDAC1 HDAC2 HDAC3 HDAC4 HDAC5 HDAC6 HSP90AA1 HSPA4 IL13RA2 ING1 KLK9 KPNA5 LRIF1 LYPD3 MCRS1 MRC2 NMI PFDN5 PSMC3IP RBBP4 RBBP7 RBP1 RELA SAP30 SIN3A SMARCE1 SMTN SNAI1 SNX6 SPOP SUDS3 TAF1 THRSP UBE2D1	20 interacting genes: AR AURKA BCAR3 BRMS1 CASP8 CHEK2 ERBB2 ESR1 ESR2 FGFR4 FZR1 NOTCH2 NR3C1 PIK3CA PSMC3 RB1CC1 RXRA TGFB1 THRB XRCC3
Entrez ID		25855	29893
HPRD ID		05879	16362
Ensembl ID		ENSG00000174744	ENSG00000131470
Uniprot IDs		G5E9I4 Q9HCU9	A0A158RUX1 K7ERB6 Q9P2W1
PDB IDs		2XUS 4AUV
Enriched GO Terms of Interacting Partners?
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