BRMS1 and IL13RA2

Data Source:
BioGRID (two hybrid)

		BRMS1	IL13RA2
Description		BRMS1 transcriptional repressor and anoikis regulator	interleukin 13 receptor subunit alpha 2
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Sin3-type Complex	Extracellular Region Extracellular Space External Side Of Plasma Membrane Integral Component Of Membrane Receptor Complex
	Molecular Function	Protein Binding Histone Deacetylase Binding NF-kappaB Binding	Cytokine Receptor Activity Protein Binding Cytokine Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Apoptotic Process Histone Deacetylation Negative Regulation Of NF-kappaB Transcription Factor Activity Regulation Of Apoptotic Process Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Protein Deacetylation Positive Regulation Of Anoikis	Negative Regulation Of Immunoglobulin Production Immunoglobulin Mediated Immune Response Cytokine-mediated Signaling Pathway Negative Regulation Of Mast Cell Degranulation
Pathways		HDACs deacetylate histones Potential therapeutics for SARS	Interleukin-4 and Interleukin-13 signaling
Drugs			AER001
Diseases
GWAS		Bipolar disorder ( 21926972 31043756)
Interacting Genes		49 interacting genes: ANGPTL4 APP ARID4A BEX2 BRMS1L CEP70 CSNK2A1 CYTOR DIRAS3 DNAJB1 DNAJB6 E2F1 EEF1A1 EP300 GOLGB1 HDAC1 HDAC2 HDAC3 HDAC4 HDAC5 HDAC6 HSP90AA1 HSPA4 IL13RA2 ING1 KLK9 KPNA5 LRIF1 LYPD3 MCRS1 MRC2 NMI PFDN5 PSMC3IP RBBP4 RBBP7 RBP1 RELA SAP30 SIN3A SMARCE1 SMTN SNAI1 SNX6 SPOP SUDS3 TAF1 THRSP UBE2D1	17 interacting genes: AKT1 BAG4 BRMS1 CASP8 EGFR ERBB2 ESR2 IGF1R IL13 IL4 IL4R NOTCH2 PALB2 PAX2 PIK3CA PLPP6 RB1CC1
Entrez ID		25855	3598
HPRD ID		05879	02132
Ensembl ID		ENSG00000174744	ENSG00000123496
Uniprot IDs		G5E9I4 Q9HCU9	Q14627
PDB IDs		2XUS 4AUV	3LB6
Enriched GO Terms of Interacting Partners?
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