KPNA5 and NUP50

Data Source:
BioGRID (two hybrid)

		KPNA5	NUP50
Description		karyopherin subunit alpha 5	nucleoporin 50
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytosol	Nuclear Pore Nucleoplasm Nuclear Membrane Host Cell
	Molecular Function	Protein Binding Nuclear Localization Sequence Binding Nuclear Import Signal Receptor Activity	Protein Binding
	Biological Process	NLS-bearing Protein Import Into Nucleus Modulation By Virus Of Host Cellular Process	Regulation Of Glycolytic Process MRNA Export From Nucleus TRNA Export From Nucleus Protein Import Into Nucleus Viral Process Protein Sumoylation Viral Transcription Regulation Of Gene Silencing By MiRNA Intracellular Transport Of Virus Regulation Of Cellular Response To Heat
Pathways		ISG15 antiviral mechanism NS1 Mediated Effects on Host Pathways	ISG15 antiviral mechanism Transport of the SLBP independent Mature mRNA Transport of the SLBP Dependant Mature mRNA Transport of Mature mRNA Derived from an Intronless Transcript Transport of Mature mRNA derived from an Intron-Containing Transcript Rev-mediated nuclear export of HIV RNA Transport of Ribonucleoproteins into the Host Nucleus NS1 Mediated Effects on Host Pathways Viral Messenger RNA Synthesis NEP/NS2 Interacts with the Cellular Export Machinery Regulation of Glucokinase by Glucokinase Regulatory Protein Nuclear import of Rev protein Vpr-mediated nuclear import of PICs snRNP Assembly SUMOylation of DNA damage response and repair proteins SUMOylation of ubiquitinylation proteins Nuclear Pore Complex (NPC) Disassembly Regulation of HSF1-mediated heat shock response SUMOylation of SUMOylation proteins SUMOylation of chromatin organization proteins SUMOylation of RNA binding proteins SUMOylation of DNA replication proteins SUMOylation of DNA replication proteins Transcriptional regulation by small RNAs Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC) tRNA processing in the nucleus HCMV Early Events HCMV Late Events
Drugs
Diseases
GWAS		Early cardiac repolarization ( 31600170) Telomere length ( 21460395)	Mean corpuscular volume ( 32888494)
Interacting Genes		28 interacting genes: ANP32A ANP32B ARNT BRMS1 CDKN1B DCPS EPAS1 FAM214B FBXO7 HIF1A HNRNPC IL32 KAT5 LMNB1 MLH1 NMNAT1 NRF1 NUP50 POLR3C POU6F2 RAD52 RBBP4 SPOP SPOPL TSEN54 TWIST1 WT1 ZNF326	14 interacting genes: APP CDKN1B IPO13 KEAP1 KPNA1 KPNA2 KPNA3 KPNA4 KPNA5 KPNA6 KPNB1 RAN SRPK2 XPO1
Entrez ID		3841	10762
HPRD ID		05179	05226
Ensembl ID		ENSG00000196911	ENSG00000093000
Uniprot IDs		O15131	A0A024R4X7 B4E2D3 Q9UKX7
PDB IDs		4U2X	2EC1 3TJ3
Enriched GO Terms of Interacting Partners?
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