KPNA5 and TSEN54

Data Source:
BioGRID (two hybrid)

		KPNA5	TSEN54
Description		karyopherin subunit alpha 5	tRNA splicing endonuclease subunit 54
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytosol	TRNA-intron Endonuclease Complex Nucleoplasm Nucleolus
	Molecular Function	Protein Binding Nuclear Localization Sequence Binding Nuclear Import Signal Receptor Activity	Protein Binding
	Biological Process	NLS-bearing Protein Import Into Nucleus Modulation By Virus Of Host Cellular Process	TRNA-type Intron Splice Site Recognition And Cleavage TRNA Splicing, Via Endonucleolytic Cleavage And Ligation MRNA Processing
Pathways		ISG15 antiviral mechanism NS1 Mediated Effects on Host Pathways	tRNA processing in the nucleus
Drugs
Diseases			Pontocerebellar hypoplasia
GWAS		Early cardiac repolarization ( 31600170) Telomere length ( 21460395)	Deep white matter hyperintensities ( 32517579) FEV1 ( 30804560) Lung function (FEV1) ( 28166213) Lung function (FEV1/FVC) ( 30804560) Lung function (FVC) ( 30804560) Lung function in never smokers (high FEV1 vs average FEV1) ( 26423011) Lung function in never smokers (low FEV1 vs high FEV1) ( 26423011) Platelet count ( 32888494) Plateletcrit ( 32888494) Sight-threatening diabetic retinopathy in type 2 diabetes ( 26188370)
Interacting Genes		28 interacting genes: ANP32A ANP32B ARNT BRMS1 CDKN1B DCPS EPAS1 FAM214B FBXO7 HIF1A HNRNPC IL32 KAT5 LMNB1 MLH1 NMNAT1 NRF1 NUP50 POLR3C POU6F2 RAD52 RBBP4 SPOP SPOPL TSEN54 TWIST1 WT1 ZNF326	21 interacting genes: BRCA1 CCDC57 CLP1 CSNK2B GOLGA6L9 IRF4 KPNA5 KRT31 LHX3 LHX4 LMO2 MCPH1 MRPL38 NAA10 NCKIPSD NFKBID RINT1 TRIM23 TRIML2 TSEN2 ZMYND12
Entrez ID		3841	283989
HPRD ID		05179	12291
Ensembl ID		ENSG00000196911	ENSG00000182173
Uniprot IDs		O15131	Q7Z6J9
PDB IDs		4U2X
Enriched GO Terms of Interacting Partners?
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