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TRIM23 and MLH1
Data Source:
BioGRID
(two hybrid)
TRIM23
MLH1
Description
tripartite motif containing 23
mutL homolog 1
Image
GO Annotations
Cellular Component
Golgi Membrane
Nucleus
Cytoplasm
Lysosomal Membrane
Plasma Membrane
Synaptonemal Complex
Male Germ Cell Nucleus
Nucleus
Nucleoplasm
Chromosome
Late Recombination Nodule
Membrane
Mismatch Repair Complex
MutLalpha Complex
Molecular Function
GTPase Activity
Ubiquitin-protein Transferase Activity
Protein Binding
GTP Binding
Enzyme Activator Activity
Zinc Ion Binding
GDP Binding
Identical Protein Binding
Chromatin Binding
Single-stranded DNA Binding
Protein Binding
ATP Binding
ATPase Activity
Enzyme Binding
Guanine/thymine Mispair Binding
MutSalpha Complex Binding
Biological Process
Intracellular Protein Transport
Viral Process
Vesicle-mediated Transport
Protein Ubiquitination
Innate Immune Response
Regulation Of Catalytic Activity
Nuclear-transcribed MRNA Poly(A) Tail Shortening
Resolution Of Meiotic Recombination Intermediates
Mismatch Repair
Double-strand Break Repair Via Nonhomologous End Joining
Male Meiosis Chromosome Segregation
Homologous Chromosome Pairing At Meiosis
Spermatogenesis
Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage
Response To Bacterium
Female Meiosis Chromosome Segregation
Somatic Hypermutation Of Immunoglobulin Genes
Meiotic Metaphase I Plate Congression
Meiotic Telomere Clustering
Isotype Switching
Negative Regulation Of Mitotic Recombination
Positive Regulation Of Isotype Switching To IgA Isotypes
Positive Regulation Of Isotype Switching To IgG Isotypes
Oogenesis
Meiotic Spindle Midzone Assembly
Pathways
Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)
Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)
Defective Mismatch Repair Associated With MLH1
Defective Mismatch Repair Associated With PMS2
TP53 Regulates Transcription of DNA Repair Genes
Meiotic recombination
Drugs
Diseases
Colorectal cancer
Mismatch repair deficiency, including: Hereditary non-polyposis colorectal cancer (HNPCC); Lynch syndrome; Muir-Torre syndrome; Turcot syndrome
Endometrial Cancer
Ovarian cancer
GWAS
Brain morphology (MOSTest) (
32665545
)
Cortical surface area (MOSTest) (
32665545
)
Subcortical volume (MOSTest) (
32665545
)
Autism spectrum disorder or schizophrenia (
28540026
)
Platelet distribution width (
32888494
)
Schizophrenia (
28991256
)
Subjective response to lithium treatment (
26503763
)
Interacting Genes
218 interacting genes:
ACTN4
AKTIP
ANKRD36BP1
ANKRD55
AP3M1
AQP1
ARFGAP1
ARHGEF3
ARNT2
ATPAF2
ATXN7
BAG1
BAZ2B
BICRAL
BRME1
C2CD6
C8orf33
CARD9
CBX8
CCDC13
CCDC146
CCDC25
CCDC33
CDC20B
CDC73
CDR2
CFAP53
CHP1P2
COX5B
CPNE7
CREB5
CSRP2
CWF19L2
CXCL14
CYTH1
CYTH2
DCX
DEPP1
DMC1
DMRT3
DNAAF4
DOCK2
EAF2
EHHADH
EIF3D
ENKD1
EPN2
EXOC3-AS1
FAM110A
FAM133A
FAM193B
FAM83A
FAM90A1
FBF1
FHIT
FLAD1
FXR2
GAD1
GATA2
GCC2-AS1
GEM
GGA2
GGA3
GLIDR
GMCL2
GPANK1
GPKOW
HAPLN2
HAUS1
HGS
HNRNPLL
HOXB5
HSPB7
IL16
IQCE
IQUB
JOSD1
JRK
KAT5
KIFC3
KLHL42
KRT6A
KRT75
KRT76
LAGE3
LENG1
LGALS14
LGALS3
LGALS8
LINC00526
LINC01018
LMO2
LMO3
LNX1
MDM2
MKRN3
MLH1
MORN4
MRPL4
MRPL45
MSRB3
MTFR2
MYEF2
MYOM1
MYOZ1
NAB2
NEDD9
NEK6
NFU1
NOXA1
NTAQ1
NUDT21
NXT2
PDE4D
PHF1
PIAS2
PIK3R2
PITX1
PKP4
PLEKHA2
POLI
POLL
POM121
PPIL2
PPP1R15B
PPP1R18
PRPF18
PRPF31
PSMA1
PSMB1
RAD18
RAMAC
RCAN3
RIBC1
RIBC2
RIN1
RNF126
RNF213
RNF32
RNF34
RNF6
RSRC2
RTP5
RUFY1
SCNM1
SF1
SH2D4A
SIAH1
SIRPA
SLC25A6
SMG9
SNAI1
SNAI2
SNRPB
SNRPB2
SNW1
SORBS3
SPG21
STK19
SUMO1P1
TACO1
TASOR2
TBC1D22B
TCEA2
TCEANC
TEPSIN
TEX33
TMSB4X
TNFAIP3
TRAF1
TRAIP
TRIM27
TRIM29
TRIM31
TRIM32
TRIM42
TRIM55
TRIM63
TROAP
TSEN54
TSG101
TSHZ3
TXNDC5
UBC
UBE2D1
UBE2D2
UBE2D3
UBE2D4
UBE2E1
UBE2E2
UBE2H
UBE2I
UBE2L3
UBE2N
UBE2U
UBE2W
UBOX5
UBQLN1
USP2
USP20
USP21
UTP23
VGLL1
WDR25
ZBTB16
ZBTB4
ZC2HC1C
ZFAND2A
ZNF20
ZNF250
ZNF408
ZNF417
ZNF474
ZNF564
ZNF581
ZNF587
ZNF688
ZNF835
139 interacting genes:
ABCC3
ABHD16A
ACER3
ACTG2
AGR2
AIFM1
ALDOA
ALDOB
ANXA6
AP1B1
AP2B1
APRT
ARAF
ASS1
ATF2
BAAT
BLM
BRCA1
BTBD2
C9orf152
CAB39L
CAPN5
CASP3
CBY2
CCDC180
CCDC33
CCDC74B
CDCA7L
CDKL5
CEP126
CEP76
CKAP4
CKB
CTSV
CYLC2
DDX47
EEF1G
EEF2
EIF2A
ELP6
ENKD1
EXO1
EXOC3
FAM228A
FAM50B
FAM90A1
FAN1
FBXO32
FCGBP
FLNB
FRAT2
FRMD6
GABARAP
GSTP1
HDAC6
IGKC
ISY1
KPNA2
KPNA5
KPRP
LEF1
LGALS4
LUC7L3
LY96
MAGEA8
MAP2K6
MBD3L1
MBD4
MLH3
MORN3
MPG
MSH3
MSH4
MUC2
MYC
MYL6
MYOG
NANOS3
NDRG1
NELFA
NFIX
NME4
NT5C3B
ORC4
PARP12
PARVA
PCNA
PER2
PIP4K2B
PMS1
PMS2
PPP1R13B
PPP2CB
PRR5L
PSMA1
PTGDS
PTPN3
PTPRH
RAD23B
RAD9A
RADX
RAPGEFL1
RBM48
RSPH3
SEC61A1
SELENBP1
SERPINF1
SMAD1
SPATA8
SQSTM1
STAP2
STX17
SYF2
TASOR2
TDRD7
TFAP2D
TLE5
TRIM23
TRIM29
TRMO
TSGA13
TXN
TXN2
U2AF1
U2AF1L5
UBOX5
VAMP8
XPA
ZBED1
ZC3H11A
ZER1
ZFP57
ZFP90
ZMAT5
ZNF177
ZNF212
ZNF474
ZNF559-ZNF177
ZNF774
Entrez ID
373
4292
HPRD ID
03449
00390
Ensembl ID
ENSG00000113595
ENSG00000076242
Uniprot IDs
P36406
A0A024R2S9
P40692
Q59EG3
PDB IDs
5VZV
5VZW
3RBN
4P7A
5U5P
Enriched GO Terms of Interacting Partners
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Tagcloud (Intersection)
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