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TRIM23 and TNFAIP3
Data Source:
BioGRID
(two hybrid, two hybrid)
TRIM23
TNFAIP3
Description
tripartite motif containing 23
TNF alpha induced protein 3
Image
GO Annotations
Cellular Component
Golgi Membrane
Nucleus
Cytoplasm
Lysosomal Membrane
Plasma Membrane
Nucleus
Cytoplasm
Lysosome
Cytosol
Extracellular Exosome
Molecular Function
GTPase Activity
Ubiquitin-protein Transferase Activity
Protein Binding
GTP Binding
Enzyme Activator Activity
Zinc Ion Binding
GDP Binding
Identical Protein Binding
Protease Binding
DNA Binding
Ubiquitin-protein Transferase Activity
Thiol-dependent Ubiquitin-specific Protease Activity
Protein Binding
Protein C-terminus Binding
Cysteine-type Peptidase Activity
Zinc Ion Binding
Kinase Binding
Identical Protein Binding
Ubiquitin Binding
Protein Self-association
Lys63-specific Deubiquitinase Activity
K63-linked Polyubiquitin Modification-dependent Protein Binding
Biological Process
Intracellular Protein Transport
Viral Process
Vesicle-mediated Transport
Protein Ubiquitination
Innate Immune Response
Regulation Of Catalytic Activity
B-1 B Cell Homeostasis
Response To Molecule Of Bacterial Origin
Regulation Of Germinal Center Formation
Negative Regulation Of Chronic Inflammatory Response
Apoptotic Process
Inflammatory Response
Cytoskeleton Organization
Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway
Cell Migration
Protein Deubiquitination
Protein Phosphopantetheinylation
Positive Regulation Of Wnt Signaling Pathway
Negative Regulation Of Protein Ubiquitination
Negative Regulation Of NF-kappaB Transcription Factor Activity
Negative Regulation Of Type I Interferon Production
Response To Muramyl Dipeptide
Negative Regulation Of Interleukin-1 Beta Production
Negative Regulation Of Interleukin-2 Production
Negative Regulation Of Interleukin-6 Production
Negative Regulation Of Tumor Necrosis Factor Production
Negative Regulation Of Toll-like Receptor 2 Signaling Pathway
Negative Regulation Of Toll-like Receptor 3 Signaling Pathway
Negative Regulation Of Toll-like Receptor 4 Signaling Pathway
Negative Regulation Of Toll-like Receptor 5 Signaling Pathway
Protein K29-linked Deubiquitination
Protein K11-linked Deubiquitination
Negative Regulation Of I-kappaB Kinase/NF-kappaB Signaling
Positive Regulation Of Protein Catabolic Process
Negative Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity
Negative Regulation Of Bone Resorption
Negative Regulation Of Innate Immune Response
Negative Regulation Of Smooth Muscle Cell Proliferation
Regulation Of Defense Response To Virus By Host
Negative Regulation Of Inflammatory Response
Negative Regulation Of B Cell Activation
Regulation Of Vascular Wound Healing
Cellular Response To Hydrogen Peroxide
Nucleotide-binding Oligomerization Domain Containing Signaling Pathway
Negative Regulation Of Nucleotide-binding Oligomerization Domain Containing 1 Signaling Pathway
Negative Regulation Of Nucleotide-binding Oligomerization Domain Containing 2 Signaling Pathway
Protein K63-linked Deubiquitination
Protein K48-linked Ubiquitination
Protein K48-linked Deubiquitination
Cellular Response To Lipopolysaccharide
Protein Deubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process
Tolerance Induction To Lipopolysaccharide
Establishment Of Protein Localization To Vacuole
Negative Regulation Of Osteoclast Proliferation
Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors
Positive Regulation Of Cellular Protein Catabolic Process
Protein K33-linked Deubiquitination
Positive Regulation Of Hepatocyte Proliferation
Negative Regulation Of CD40 Signaling Pathway
Negative Regulation Of Endothelial Cell Apoptotic Process
Pathways
NOD1/2 Signaling Pathway
TNFR1-induced proapoptotic signaling
Regulation of TNFR1 signaling
TNFR1-induced NFkappaB signaling pathway
Ovarian tumor domain proteases
Negative regulators of DDX58/IFIH1 signaling
Drugs
Diseases
GWAS
Brain morphology (MOSTest) (
32665545
)
Cortical surface area (MOSTest) (
32665545
)
Subcortical volume (MOSTest) (
32665545
)
Allergic disease (asthma, hay fever or eczema) (
29083406
)
Asthma (
32296059
)
Autoimmune traits (pleiotropy) (
30572963
)
Cardiac Troponin-T levels (
23247143
)
Celiac disease (
22057235
20190752
)
Celiac disease and Rheumatoid arthritis (
26546613
)
Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) (
26974007
)
Cutaneous psoriasis (
26626624
)
Hodgkin's lymphoma (
30194254
)
Inflammatory bowel disease (
23128233
)
Inflammatory skin disease (
25574825
)
Malaria (
31844061
)
Multiple sclerosis (
24076602
)
Phosphatidylcholine-ether levels (
31551469
)
Primary biliary cholangitis (
26394269
)
Psoriasis (
25903422
20953190
25574825
23143594
19169254
)
Psoriasis vulgaris (
26626624
)
Rheumatoid arthritis (
24449572
30423114
23143596
24390342
20453841
20453842
17982456
)
Rheumatoid arthritis (ACPA-positive) (
23143596
24532676
)
Sjögren's syndrome (
24097066
24097067
)
Systemic lupus erythematosus (
27399966
23273568
26663301
26502338
19165918
28714469
19838193
19838195
)
Systemic lupus erythematosus and Systemic sclerosis (
23740937
)
Systemic lupus erythematosus or rheumatoid arthritis (
27193031
)
Systemic sclerosis (
28314753
)
Systemic seropositive rheumatic diseases (Systemic sclerosis or systemic lupus erythematosus or rheumatoid arthritis or idiopathic inflammatory myopathies) (
30573655
)
Tonsillectomy (
27182965
28928442
)
Interacting Genes
218 interacting genes:
ACTN4
AKTIP
ANKRD36BP1
ANKRD55
AP3M1
AQP1
ARFGAP1
ARHGEF3
ARNT2
ATPAF2
ATXN7
BAG1
BAZ2B
BICRAL
BRME1
C2CD6
C8orf33
CARD9
CBX8
CCDC13
CCDC146
CCDC25
CCDC33
CDC20B
CDC73
CDR2
CFAP53
CHP1P2
COX5B
CPNE7
CREB5
CSRP2
CWF19L2
CXCL14
CYTH1
CYTH2
DCX
DEPP1
DMC1
DMRT3
DNAAF4
DOCK2
EAF2
EHHADH
EIF3D
ENKD1
EPN2
EXOC3-AS1
FAM110A
FAM133A
FAM193B
FAM83A
FAM90A1
FBF1
FHIT
FLAD1
FXR2
GAD1
GATA2
GCC2-AS1
GEM
GGA2
GGA3
GLIDR
GMCL2
GPANK1
GPKOW
HAPLN2
HAUS1
HGS
HNRNPLL
HOXB5
HSPB7
IL16
IQCE
IQUB
JOSD1
JRK
KAT5
KIFC3
KLHL42
KRT6A
KRT75
KRT76
LAGE3
LENG1
LGALS14
LGALS3
LGALS8
LINC00526
LINC01018
LMO2
LMO3
LNX1
MDM2
MKRN3
MLH1
MORN4
MRPL4
MRPL45
MSRB3
MTFR2
MYEF2
MYOM1
MYOZ1
NAB2
NEDD9
NEK6
NFU1
NOXA1
NTAQ1
NUDT21
NXT2
PDE4D
PHF1
PIAS2
PIK3R2
PITX1
PKP4
PLEKHA2
POLI
POLL
POM121
PPIL2
PPP1R15B
PPP1R18
PRPF18
PRPF31
PSMA1
PSMB1
RAD18
RAMAC
RCAN3
RIBC1
RIBC2
RIN1
RNF126
RNF213
RNF32
RNF34
RNF6
RSRC2
RTP5
RUFY1
SCNM1
SF1
SH2D4A
SIAH1
SIRPA
SLC25A6
SMG9
SNAI1
SNAI2
SNRPB
SNRPB2
SNW1
SORBS3
SPG21
STK19
SUMO1P1
TACO1
TASOR2
TBC1D22B
TCEA2
TCEANC
TEPSIN
TEX33
TMSB4X
TNFAIP3
TRAF1
TRAIP
TRIM27
TRIM29
TRIM31
TRIM32
TRIM42
TRIM55
TRIM63
TROAP
TSEN54
TSG101
TSHZ3
TXNDC5
UBC
UBE2D1
UBE2D2
UBE2D3
UBE2D4
UBE2E1
UBE2E2
UBE2H
UBE2I
UBE2L3
UBE2N
UBE2U
UBE2W
UBOX5
UBQLN1
USP2
USP20
USP21
UTP23
VGLL1
WDR25
ZBTB16
ZBTB4
ZC2HC1C
ZFAND2A
ZNF20
ZNF250
ZNF408
ZNF417
ZNF474
ZNF564
ZNF581
ZNF587
ZNF688
ZNF835
47 interacting genes:
ARRDC3
CCDC50
CHUK
GAS8
GIT2
GSK3B
IKBKB
IKBKG
LAPTM5
LNX1
MAP3K5
OCLN
PFKL
PIBF1
RAD23A
RBCK1
RIPK1
RLIM
RNF11
RNF14
RNF168
RNF216
RNF5
SNAI1
TAX1BP1
TICAM1
TNIP1
TNIP2
TNIP3
TRAF1
TRAF2
TRAF6
TRIM2
TRIM23
TRIM3
TRIM5
TRIM8
UBC
UBE2D1
UBE2N
YWHAB
YWHAE
YWHAG
YWHAH
YWHAQ
YWHAZ
ZFAND5
Entrez ID
373
7128
HPRD ID
03449
01857
Ensembl ID
ENSG00000113595
ENSG00000118503
Uniprot IDs
P36406
P21580
PDB IDs
5VZV
5VZW
2EQE
2EQF
2EQG
2VFJ
3DKB
3OJ3
3OJ4
3VUW
3VUX
3VUY
3ZJD
3ZJE
3ZJF
3ZJG
5LRX
5V3B
5V3P
Enriched GO Terms of Interacting Partners
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Tagcloud (Intersection)
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