TRIM23 and GATA2

Data Source:
BioGRID (two hybrid)

		TRIM23	GATA2
Description		tripartite motif containing 23	GATA binding protein 2
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GO Annotations	Cellular Component	Golgi Membrane Nucleus Cytoplasm Lysosomal Membrane Plasma Membrane	Nucleus Nucleoplasm Transcription Regulator Complex Cytoplasm
	Molecular Function	GTPase Activity Ubiquitin-protein Transferase Activity Protein Binding GTP Binding Enzyme Activator Activity Zinc Ion Binding GDP Binding Identical Protein Binding	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Chromatin Binding DNA-binding Transcription Factor Activity Protein Binding Transcription Factor Binding Zinc Ion Binding C2H2 Zinc Finger Domain Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Intracellular Protein Transport Viral Process Vesicle-mediated Transport Protein Ubiquitination Innate Immune Response Regulation Of Catalytic Activity	Urogenital System Development Cell Fate Determination Neuron Migration Embryonic Placenta Development Regulation Of Transcription By RNA Polymerase II Phagocytosis Positive Regulation Of Cytosolic Calcium Ion Concentration Blood Coagulation Positive Regulation Of Gene Expression Negative Regulation Of Gene Expression Regulation Of Primitive Erythrocyte Differentiation Ventral Spinal Cord Interneuron Differentiation Cell Differentiation In Hindbrain Commitment Of Neuronal Cell To Specific Neuron Type In Forebrain Central Nervous System Neuron Development Pituitary Gland Development Response To Lipid Somatic Stem Cell Population Maintenance Regulation Of Histone Acetylation Eosinophil Fate Commitment Inner Ear Morphogenesis Positive Regulation Of Mast Cell Degranulation Positive Regulation Of Blood Vessel Endothelial Cell Migration Cell Fate Commitment Negative Regulation Of Fat Cell Differentiation Positive Regulation Of Erythrocyte Differentiation Negative Regulation Of Macrophage Differentiation Positive Regulation Of Megakaryocyte Differentiation Positive Regulation Of Neuron Differentiation Negative Regulation Of Notch Signaling Pathway Positive Regulation Of Angiogenesis Positive Regulation Of Transcription By RNA Polymerase II Cell Maturation Homeostasis Of Number Of Cells Within A Tissue Positive Regulation Of Phagocytosis Positive Regulation Of Phagocytosis, Engulfment Definitive Hemopoiesis Semicircular Canal Development Vascular Wound Healing Negative Regulation Of Fat Cell Proliferation Positive Regulation Of Cell Migration Involved In Sprouting Angiogenesis Cochlea Development GABAergic Neuron Differentiation Regulation Of Hematopoietic Stem Cell Differentiation Positive Regulation Of Pri-miRNA Transcription By RNA Polymerase II Positive Regulation Of Blood Vessel Endothelial Cell Proliferation Involved In Sprouting Angiogenesis Negative Regulation Of Neural Precursor Cell Proliferation Negative Regulation Of Endothelial Cell Apoptotic Process Regulation Of Forebrain Neuron Differentiation
Pathways			RUNX1 regulates transcription of genes involved in differentiation of HSCs Transcriptional regulation of granulopoiesis Factors involved in megakaryocyte development and platelet production
Drugs
Diseases
GWAS		Brain morphology (MOSTest) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Subcortical volume (MOSTest) ( 32665545)	Basophil count ( 28031487) Chronic obstructive pulmonary disease or high blood pressure (pleiotropy) ( 30940143) Diastolic blood pressure ( 30578418) Eosinophil counts ( 19198610) Lymphocyte counts ( 32888494) Lymphocyte percentage of white cells ( 32888494 27863252) Monocyte count ( 32888494) Monocyte percentage of white cells ( 32888494) Myeloproliferative neoplasms ( 33057200) Neutrophil count ( 32888494) Neutrophil percentage of white cells ( 32888494 27863252) Plateletcrit ( 32888494) Preterm birth (maternal effect) ( 28877031) Prostate cancer ( 31562322) Pulse pressure ( 28135244 27841878 30578418) Systolic blood pressure ( 27841878) White blood cell count ( 21738480) White blood cell count (basophil) ( 28158719) White blood cell count (eosinophil) ( 28158719) White blood cell types ( 21738478)
Interacting Genes		218 interacting genes: ACTN4 AKTIP ANKRD36BP1 ANKRD55 AP3M1 AQP1 ARFGAP1 ARHGEF3 ARNT2 ATPAF2 ATXN7 BAG1 BAZ2B BICRAL BRME1 C2CD6 C8orf33 CARD9 CBX8 CCDC13 CCDC146 CCDC25 CCDC33 CDC20B CDC73 CDR2 CFAP53 CHP1P2 COX5B CPNE7 CREB5 CSRP2 CWF19L2 CXCL14 CYTH1 CYTH2 DCX DEPP1 DMC1 DMRT3 DNAAF4 DOCK2 EAF2 EHHADH EIF3D ENKD1 EPN2 EXOC3-AS1 FAM110A FAM133A FAM193B FAM83A FAM90A1 FBF1 FHIT FLAD1 FXR2 GAD1 GATA2 GCC2-AS1 GEM GGA2 GGA3 GLIDR GMCL2 GPANK1 GPKOW HAPLN2 HAUS1 HGS HNRNPLL HOXB5 HSPB7 IL16 IQCE IQUB JOSD1 JRK KAT5 KIFC3 KLHL42 KRT6A KRT75 KRT76 LAGE3 LENG1 LGALS14 LGALS3 LGALS8 LINC00526 LINC01018 LMO2 LMO3 LNX1 MDM2 MKRN3 MLH1 MORN4 MRPL4 MRPL45 MSRB3 MTFR2 MYEF2 MYOM1 MYOZ1 NAB2 NEDD9 NEK6 NFU1 NOXA1 NTAQ1 NUDT21 NXT2 PDE4D PHF1 PIAS2 PIK3R2 PITX1 PKP4 PLEKHA2 POLI POLL POM121 PPIL2 PPP1R15B PPP1R18 PRPF18 PRPF31 PSMA1 PSMB1 RAD18 RAMAC RCAN3 RIBC1 RIBC2 RIN1 RNF126 RNF213 RNF32 RNF34 RNF6 RSRC2 RTP5 RUFY1 SCNM1 SF1 SH2D4A SIAH1 SIRPA SLC25A6 SMG9 SNAI1 SNAI2 SNRPB SNRPB2 SNW1 SORBS3 SPG21 STK19 SUMO1P1 TACO1 TASOR2 TBC1D22B TCEA2 TCEANC TEPSIN TEX33 TMSB4X TNFAIP3 TRAF1 TRAIP TRIM27 TRIM29 TRIM31 TRIM32 TRIM42 TRIM55 TRIM63 TROAP TSEN54 TSG101 TSHZ3 TXNDC5 UBC UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2E1 UBE2E2 UBE2H UBE2I UBE2L3 UBE2N UBE2U UBE2W UBOX5 UBQLN1 USP2 USP20 USP21 UTP23 VGLL1 WDR25 ZBTB16 ZBTB4 ZC2HC1C ZFAND2A ZNF20 ZNF250 ZNF408 ZNF417 ZNF474 ZNF564 ZNF581 ZNF587 ZNF688 ZNF835	46 interacting genes: ADAMTSL4 AKT1 CDK1 CEBPA CYSRT1 EP300 FBXW7 FHL3 GOLGA2 HDAC3 HDAC5 HHEX JUN KAT2A KRT40 KRTAP10-3 KRTAP10-9 KRTAP11-1 KRTAP13-3 KRTAP21-2 KRTAP3-1 KRTAP6-3 KRTAP7-1 KRTAP8-1 LMO2 MAPK1 MDFI MSX2 NOTCH2NLA PML POU1F1 POU2AF1 PRR20A PSMA3 RARA RBPMS RXRA SMAD4 SPI1 STAT3 TAL1 TRAF1 TRIM23 ZBTB16 ZBTB32 ZFPM1
Entrez ID		373	2624
HPRD ID		03449	00673
Ensembl ID		ENSG00000113595	ENSG00000179348
Uniprot IDs		P36406	P23769
PDB IDs		5VZV 5VZW	5O9B
Enriched GO Terms of Interacting Partners?
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