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MLH1 and EEF2
Data Source:
BioGRID
(two hybrid)
MLH1
EEF2
Description
mutL homolog 1
eukaryotic translation elongation factor 2
Image
GO Annotations
Cellular Component
Synaptonemal Complex
Male Germ Cell Nucleus
Nucleus
Nucleoplasm
Chromosome
Late Recombination Nodule
Membrane
Mismatch Repair Complex
MutLalpha Complex
Extracellular Region
Nucleus
Cytoplasm
Cytosol
Plasma Membrane
Membrane
Aggresome
Secretory Granule Lumen
Polysomal Ribosome
Membrane Raft
Synapse
Extracellular Exosome
Ficolin-1-rich Granule Lumen
Ribonucleoprotein Complex
Molecular Function
Chromatin Binding
Single-stranded DNA Binding
Protein Binding
ATP Binding
ATPase Activity
Enzyme Binding
Guanine/thymine Mispair Binding
MutSalpha Complex Binding
P53 Binding
RNA Binding
Translation Elongation Factor Activity
GTPase Activity
Protein Binding
GTP Binding
5S RRNA Binding
Protein Kinase Binding
Ribosome Binding
Cadherin Binding
Actin Filament Binding
Biological Process
Nuclear-transcribed MRNA Poly(A) Tail Shortening
Resolution Of Meiotic Recombination Intermediates
Mismatch Repair
Double-strand Break Repair Via Nonhomologous End Joining
Male Meiosis Chromosome Segregation
Homologous Chromosome Pairing At Meiosis
Spermatogenesis
Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage
Response To Bacterium
Female Meiosis Chromosome Segregation
Somatic Hypermutation Of Immunoglobulin Genes
Meiotic Metaphase I Plate Congression
Meiotic Telomere Clustering
Isotype Switching
Negative Regulation Of Mitotic Recombination
Positive Regulation Of Isotype Switching To IgA Isotypes
Positive Regulation Of Isotype Switching To IgG Isotypes
Oogenesis
Meiotic Spindle Midzone Assembly
Hematopoietic Progenitor Cell Differentiation
Response To Ischemia
Skeletal Muscle Contraction
Translational Elongation
Aging
Glial Cell Proliferation
Response To Estradiol
Response To Endoplasmic Reticulum Stress
Skeletal Muscle Cell Differentiation
Response To Drug
Response To Hydrogen Peroxide
Neutrophil Degranulation
Response To Ethanol
Positive Regulation Of Translation
Response To Folic Acid
Cellular Response To Brain-derived Neurotrophic Factor Stimulus
Positive Regulation Of Cytoplasmic Translation
Pathways
Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)
Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)
Defective Mismatch Repair Associated With MLH1
Defective Mismatch Repair Associated With PMS2
TP53 Regulates Transcription of DNA Repair Genes
Meiotic recombination
Peptide chain elongation
Peptide chain elongation
Uptake and function of diphtheria toxin
Synthesis of diphthamide-EEF2
Synthesis of diphthamide-EEF2
Neutrophil degranulation
Protein methylation
Drugs
Adenosine-5-Diphosphoribose
Diphthamide
Guanosine-5'-Diphosphate
N~2~,N~2~-DIMETHYL-N~1~-(6-OXO-5,6-DIHYDROPHENANTHRIDIN-2-YL)GLYCINAMIDE
Esketamine
Moxetumomab Pasudotox
Diseases
Colorectal cancer
Mismatch repair deficiency, including: Hereditary non-polyposis colorectal cancer (HNPCC); Lynch syndrome; Muir-Torre syndrome; Turcot syndrome
Endometrial Cancer
Ovarian cancer
GWAS
Autism spectrum disorder or schizophrenia (
28540026
)
Platelet distribution width (
32888494
)
Schizophrenia (
28991256
)
Subjective response to lithium treatment (
26503763
)
Interacting Genes
139 interacting genes:
ABCC3
ABHD16A
ACER3
ACTG2
AGR2
AIFM1
ALDOA
ALDOB
ANXA6
AP1B1
AP2B1
APRT
ARAF
ASS1
ATF2
BAAT
BLM
BRCA1
BTBD2
C9orf152
CAB39L
CAPN5
CASP3
CBY2
CCDC180
CCDC33
CCDC74B
CDCA7L
CDKL5
CEP126
CEP76
CKAP4
CKB
CTSV
CYLC2
DDX47
EEF1G
EEF2
EIF2A
ELP6
ENKD1
EXO1
EXOC3
FAM228A
FAM50B
FAM90A1
FAN1
FBXO32
FCGBP
FLNB
FRAT2
FRMD6
GABARAP
GSTP1
HDAC6
IGKC
ISY1
KPNA2
KPNA5
KPRP
LEF1
LGALS4
LUC7L3
LY96
MAGEA8
MAP2K6
MBD3L1
MBD4
MLH3
MORN3
MPG
MSH3
MSH4
MUC2
MYC
MYL6
MYOG
NANOS3
NDRG1
NELFA
NFIX
NME4
NT5C3B
ORC4
PARP12
PARVA
PCNA
PER2
PIP4K2B
PMS1
PMS2
PPP1R13B
PPP2CB
PRR5L
PSMA1
PTGDS
PTPN3
PTPRH
RAD23B
RAD9A
RADX
RAPGEFL1
RBM48
RSPH3
SEC61A1
SELENBP1
SERPINF1
SMAD1
SPATA8
SQSTM1
STAP2
STX17
SYF2
TASOR2
TDRD7
TFAP2D
TLE5
TRIM23
TRIM29
TRMO
TSGA13
TXN
TXN2
U2AF1
U2AF1L5
UBOX5
VAMP8
XPA
ZBED1
ZC3H11A
ZER1
ZFP57
ZFP90
ZMAT5
ZNF177
ZNF212
ZNF474
ZNF559-ZNF177
ZNF774
21 interacting genes:
CCT2
CDKN2A
DISC1
DUX4
EEF2K
EP300
ESR1
HNRNPD
LINC01554
MAPKAPK3
MLH1
NDRG1
PPM1A
PPP2CA
PPP2R1A
PPP2R1B
PTEN
SUMO2
TP53
TRPM7
UCHL5
Entrez ID
4292
1938
HPRD ID
00390
00561
Ensembl ID
ENSG00000076242
ENSG00000167658
Uniprot IDs
A0A024R2S9
P40692
Q59EG3
A0A384N6H1
P13639
PDB IDs
3RBN
4P7A
5U5P
4V6X
6D9J
6Z6M
6Z6N
Enriched GO Terms of Interacting Partners
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