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NCL and ZFP36
Data Source:
BioGRID
(two hybrid)
NCL
ZFP36
Description
nucleolin
ZFP36 ring finger protein
Image
GO Annotations
Cellular Component
Nucleus
Nucleoplasm
Spliceosomal Complex
Chromosome
Nucleolus
Cell Cortex
Membrane
Cytoplasmic Ribonucleoprotein Granule
Extracellular Exosome
Ribonucleoprotein Complex
Exosome (RNase Complex)
P-body
Nucleus
Cytoplasm
Cytosol
Cytoplasmic Stress Granule
CCR4-NOT Complex
RISC-loading Complex
Ribonucleoprotein Complex
Molecular Function
RNA Binding
Protein Binding
Protein C-terminus Binding
Telomeric DNA Binding
Identical Protein Binding
DNA Topoisomerase Binding
MRNA 5'-UTR Binding
DNA Binding
RNA Binding
MRNA Binding
Protein Binding
Enzyme Binding
Protein Kinase Binding
C-C Chemokine Binding
Heat Shock Protein Binding
MRNA 3'-UTR AU-rich Region Binding
Protein-containing Complex Binding
Metal Ion Binding
RNA Polymerase Binding
14-3-3 Protein Binding
Biological Process
Angiogenesis
Negative Regulation Of Translation
Positive Regulation Of MRNA Splicing, Via Spliceosome
Positive Regulation Of Transcription Of Nucleolar Large RRNA By RNA Polymerase I
Negative Regulation Of Transcription By RNA Polymerase II
MAPK Cascade
Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay
Nuclear-transcribed MRNA Poly(A) Tail Shortening
MRNA Catabolic Process
Response To Wounding
Regulation Of Keratinocyte Proliferation
Viral Process
Nuclear-transcribed MRNA Catabolic Process, Deadenylation-independent Decay
Regulation Of Tumor Necrosis Factor Production
Negative Regulation Of Interleukin-2 Production
Negative Regulation Of Viral Transcription
MiRNA Mediated Inhibition Of Translation
P38MAPK Cascade
Response To Starvation
Regulation Of MRNA Stability
Cellular Response To Fibroblast Growth Factor Stimulus
Positive Regulation Of Fat Cell Differentiation
Regulation Of Keratinocyte Differentiation
Negative Regulation Of Erythrocyte Differentiation
MRNA Transport
Positive Regulation Of Nuclear-transcribed MRNA Poly(A) Tail Shortening
3'-UTR-mediated MRNA Destabilization
3'-UTR-mediated MRNA Stabilization
Cellular Response To Lipopolysaccharide
Cellular Response To Tumor Necrosis Factor
Cellular Response To Epidermal Growth Factor Stimulus
Cellular Response To Glucocorticoid Stimulus
Cellular Response To Granulocyte Macrophage Colony-stimulating Factor Stimulus
Positive Regulation Of Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay
Positive Regulation Of Deadenylation-independent Decapping Of Nuclear-transcribed MRNA
Regulation Of Keratinocyte Apoptotic Process
Negative Regulation Of Polynucleotide Adenylyltransferase Activity
Positive Regulation Of Intracellular MRNA Localization
Positive Regulation Of Gene Silencing By MiRNA
Pathways
Major pathway of rRNA processing in the nucleolus and cytosol
Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA
Drugs
Diseases
GWAS
Attention deficit hyperactivity disorder (
23728934
)
Common carotid intima-media thickness in HIV negative individuals (
29206233
)
Eating disorders (purging via substances) (
23568457
)
Height (
31562340
)
Noise-induced hearing loss (
26121033
)
Interacting Genes
57 interacting genes:
ADAP1
ADAP2
CD3E
CDK1
CDKN2A
CLK1
CSNK2A1
CSNK2A2
DUX4
ERG
ESR1
ETS1
FMR1
GRB2
GZF1
GZMA
H1-2
H2AC20
H2AX
H2BC21
H3-4
HMGA1
IL7R
LINC01554
MDC1
MDK
MDM2
MYB
MYBL1
NBN
NDRG1
NPM1
NR3C1
PARP1
POLR1G
PPARGC1A
PPM1D
PRKCZ
PRMT5
PTGS1
RAD51
S100A11
SREK1
SRPK2
SSB
STAU1
SUMO2
TERF2
TERT
TOP1
TP53
VHL
XRCC6
YWHAQ
ZFP36
ZFP41
ZNF689
26 interacting genes:
APP
ATG16L1
CCDC85B
CDK6
DCP1B
DHX36
DNAJB1
EDC3
EXOSC6
EXOSC8
FHL3
HMGB1
HOXC9
MAPK1
MAPKAPK2
NCL
NUP214
RUNX1T1
SFN
TNF
UPF2
XRN1
YWHAB
YWHAG
YWHAH
ZDHHC17
Entrez ID
4691
7538
HPRD ID
01245
01835
Ensembl ID
ENSG00000115053
ENSG00000128016
Uniprot IDs
B3KM80
P19338
M0QY76
P26651
PDB IDs
2FC8
2FC9
2KRR
4J8S
Enriched GO Terms of Interacting Partners
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Tagcloud (Difference)
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Tagcloud (Intersection)
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