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NCL and H2BC21
Data Source:
BioGRID
(pull down)
NCL
H2BC21
Description
nucleolin
H2B clustered histone 21
Image
GO Annotations
Cellular Component
Nucleus
Nucleoplasm
Spliceosomal Complex
Chromosome
Nucleolus
Cell Cortex
Membrane
Cytoplasmic Ribonucleoprotein Granule
Extracellular Exosome
Ribonucleoprotein Complex
Nucleosome
Extracellular Space
Nucleus
Nucleoplasm
Cytosol
Extracellular Exosome
Molecular Function
RNA Binding
Protein Binding
Protein C-terminus Binding
Telomeric DNA Binding
Identical Protein Binding
DNA Topoisomerase Binding
MRNA 5'-UTR Binding
DNA Binding
Protein Binding
Protein Heterodimerization Activity
Biological Process
Angiogenesis
Negative Regulation Of Translation
Positive Regulation Of MRNA Splicing, Via Spliceosome
Positive Regulation Of Transcription Of Nucleolar Large RRNA By RNA Polymerase I
Innate Immune Response In Mucosa
Nucleosome Assembly
Antibacterial Humoral Response
Defense Response To Gram-positive Bacterium
Antimicrobial Humoral Immune Response Mediated By Antimicrobial Peptide
Pathways
Major pathway of rRNA processing in the nucleolus and cytosol
Recognition and association of DNA glycosylase with site containing an affected pyrimidine
Cleavage of the damaged pyrimidine
Recognition and association of DNA glycosylase with site containing an affected purine
Recognition and association of DNA glycosylase with site containing an affected purine
Cleavage of the damaged purine
Cleavage of the damaged purine
Meiotic synapsis
Packaging Of Telomere Ends
Pre-NOTCH Transcription and Translation
Formation of the beta-catenin:TCF transactivating complex
Formation of the beta-catenin:TCF transactivating complex
PRC2 methylates histones and DNA
Condensation of Prophase Chromosomes
Oxidative Stress Induced Senescence
Senescence-Associated Secretory Phenotype (SASP)
DNA Damage/Telomere Stress Induced Senescence
HDACs deacetylate histones
HATs acetylate histones
HATs acetylate histones
SIRT1 negatively regulates rRNA expression
ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression
NoRC negatively regulates rRNA expression
NoRC negatively regulates rRNA expression
B-WICH complex positively regulates rRNA expression
DNA methylation
Transcriptional regulation by small RNAs
Activation of anterior HOX genes in hindbrain development during early embryogenesis
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3
Ub-specific processing proteases
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks
Nonhomologous End-Joining (NHEJ)
Processing of DNA double-strand break ends
Deposition of new CENPA-containing nucleosomes at the centromere
G2/M DNA damage checkpoint
RNA Polymerase I Promoter Opening
RNA Polymerase I Promoter Escape
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function
RUNX1 regulates transcription of genes involved in differentiation of HSCs
Estrogen-dependent gene expression
Meiotic recombination
HCMV Early Events
HCMV Late Events
Transcriptional regulation of granulopoiesis
Inhibition of DNA recombination at telomere
Amyloid fiber formation
Drugs
Diseases
GWAS
Attention deficit hyperactivity disorder (
23728934
)
Common carotid intima-media thickness in HIV negative individuals (
29206233
)
Eating disorders (purging via substances) (
23568457
)
Height (
31562340
)
Noise-induced hearing loss (
26121033
)
Interacting Genes
57 interacting genes:
ADAP1
ADAP2
CD3E
CDK1
CDKN2A
CLK1
CSNK2A1
CSNK2A2
DUX4
ERG
ESR1
ETS1
FMR1
GRB2
GZF1
GZMA
H1-2
H2AC20
H2AX
H2BC21
H3-4
HMGA1
IL7R
LINC01554
MDC1
MDK
MDM2
MYB
MYBL1
NBN
NDRG1
NPM1
NR3C1
PARP1
POLR1G
PPARGC1A
PPM1D
PRKCZ
PRMT5
PTGS1
RAD51
S100A11
SREK1
SRPK2
SSB
STAU1
SUMO2
TERF2
TERT
TOP1
TP53
VHL
XRCC6
YWHAQ
ZFP36
ZFP41
ZNF689
77 interacting genes:
AIRE
AKT1
ANP32A
AP2M1
ARID1B
ATF2
ATXN7L3
BARD1
BRD2
BRD7
CDK9
CREBBP
DNMT3L
DYRK2
EP300
GADD45A
GATAD2A
GATAD2B
GZMA
H2AC20
HDAC2
HIPK2
HIRA
HIRIP3
HSPD1
IL33
IL7R
KAT2A
KAT2B
KPNA1
LALBA
LOX
MAP4K4
MDM2
MSL1
MSL2
NAP1L4
NCL
NPM1
PARP10
PBRM1
PELP1
PRMT6
PTMA
RAG1
RCC1
RNF168
RNF20
RNF8
RPS6KA5
SAP30
SART3
SIRT7
SMARCA4
SMU1
SPANXN2
SSRP1
STK38
STK4
TAF1A
TAF1B
TBL1X
TBL1XR1
TCF20
TGM2
TNPO1
TRAF6
TSPY1
UBC
UBE2A
USP12
USP15
USP22
USP46
USP49
USP8
VRK1
Entrez ID
4691
8349
HPRD ID
01245
03494
Ensembl ID
ENSG00000115053
ENSG00000184678
Uniprot IDs
B3KM80
P19338
Q16778
PDB IDs
2FC8
2FC9
2KRR
4NFT
6A7U
6KBB
6M4D
6M4G
6M4H
Enriched GO Terms of Interacting Partners
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Tagcloud (Intersection)
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