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NCL and NBN
Data Source:
BioGRID
(pull down)
NCL
NBN
Description
nucleolin
nibrin
Image
GO Annotations
Cellular Component
Nucleus
Nucleoplasm
Spliceosomal Complex
Chromosome
Nucleolus
Cell Cortex
Membrane
Cytoplasmic Ribonucleoprotein Granule
Extracellular Exosome
Ribonucleoprotein Complex
Chromosome, Telomeric Region
Nucleus
Nucleoplasm
Replication Fork
Nucleolus
Cytosol
PML Body
Mre11 Complex
Site Of Double-strand Break
Nuclear Inclusion Body
Molecular Function
RNA Binding
Protein Binding
Protein C-terminus Binding
Telomeric DNA Binding
Identical Protein Binding
DNA Topoisomerase Binding
MRNA 5'-UTR Binding
Damaged DNA Binding
Protein Binding
Transcription Factor Binding
Protein N-terminus Binding
Biological Process
Angiogenesis
Negative Regulation Of Translation
Positive Regulation Of MRNA Splicing, Via Spliceosome
Positive Regulation Of Transcription Of Nucleolar Large RRNA By RNA Polymerase I
DNA Damage Checkpoint
Telomere Maintenance
Double-strand Break Repair Via Homologous Recombination
DNA Double-strand Break Processing
Blastocyst Growth
DNA Replication
Double-strand Break Repair
Double-strand Break Repair Via Nonhomologous End Joining
Cell Cycle Arrest
Mitotic G2 DNA Damage Checkpoint
Cell Population Proliferation
Viral Process
Regulation Of DNA-dependent DNA Replication Initiation
DNA Damage Response, Signal Transduction By P53 Class Mediator
Telomeric 3' Overhang Formation
Positive Regulation Of Protein Autophosphorylation
Positive Regulation Of Telomere Maintenance
DNA Duplex Unwinding
Positive Regulation Of Kinase Activity
Signal Transduction In Response To DNA Damage
Isotype Switching
Neuromuscular Process Controlling Balance
Meiotic Cell Cycle
T-circle Formation
Telomere Maintenance Via Telomere Trimming
Intrinsic Apoptotic Signaling Pathway
Regulation Of Signal Transduction By P53 Class Mediator
Negative Regulation Of Telomere Capping
Pathways
Major pathway of rRNA processing in the nucleolus and cytosol
DNA Damage/Telomere Stress Induced Senescence
HDR through Single Strand Annealing (SSA)
HDR through MMEJ (alt-NHEJ)
HDR through Homologous Recombination (HRR)
Sensing of DNA Double Strand Breaks
Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks
Resolution of D-loop Structures through Holliday Junction Intermediates
Nonhomologous End-Joining (NHEJ)
Homologous DNA Pairing and Strand Exchange
Processing of DNA double-strand break ends
Presynaptic phase of homologous DNA pairing and strand exchange
Regulation of TP53 Activity through Phosphorylation
G2/M DNA damage checkpoint
Meiotic recombination
Drugs
Diseases
DNA repair defects, including the following six diseases: Ataxia telangiectasia (AT); Ataxia-talangiectasia-like syndrome; Nijmegen syndrome; DNA ligase I deficiency; DNA ligase IV deficiency; Bloom's syndrome
GWAS
Attention deficit hyperactivity disorder (
23728934
)
Common carotid intima-media thickness in HIV negative individuals (
29206233
)
Eating disorders (purging via substances) (
23568457
)
Height (
31562340
)
Noise-induced hearing loss (
26121033
)
Lymphocyte counts (
32888494
)
Lymphocyte percentage of white cells (
32888494
)
Monocyte count (
32888494
)
Interacting Genes
57 interacting genes:
ADAP1
ADAP2
CD3E
CDK1
CDKN2A
CLK1
CSNK2A1
CSNK2A2
DUX4
ERG
ESR1
ETS1
FMR1
GRB2
GZF1
GZMA
H1-2
H2AC20
H2AX
H2BC21
H3-4
HMGA1
IL7R
LINC01554
MDC1
MDK
MDM2
MYB
MYBL1
NBN
NDRG1
NPM1
NR3C1
PARP1
POLR1G
PPARGC1A
PPM1D
PRKCZ
PRMT5
PTGS1
RAD51
S100A11
SREK1
SRPK2
SSB
STAU1
SUMO2
TERF2
TERT
TOP1
TP53
VHL
XRCC6
YWHAQ
ZFP36
ZFP41
ZNF689
35 interacting genes:
ATF2
ATM
ATR
BAP1
BRCA1
CASC3
CCNE1
CDK9
CHEK2
DCLRE1C
EP300
FANCD2
H2AX
H3-4
HIF1A
MDC1
MRE11
NAT2
NCL
PRKDC
RAD18
RAD50
RAD51
RECQL5
SIRT1
SNAI1
SUMO2
TERF1
TLK1
TREX1
UBE2D1
UBE2N
VRK1
XRCC4
XRCC5
Entrez ID
4691
4683
HPRD ID
01245
04050
Ensembl ID
ENSG00000115053
ENSG00000104320
Uniprot IDs
B3KM80
P19338
A0A0C4DG07
O60934
PDB IDs
2FC8
2FC9
2KRR
5WQD
Enriched GO Terms of Interacting Partners
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Tagcloud (Difference)
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Tagcloud (Intersection)
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