ABR and PJA1

Data Source:
BioGRID (enzymatic study)

		ABR	PJA1
Description		ABR activator of RhoGEF and GTPase	praja ring finger ubiquitin ligase 1
Image		No pdb structure
GO Annotations	Cellular Component	Cytosol Membrane Axon Dendritic Spine Schaffer Collateral - CA1 Synapse Glutamatergic Synapse	Cytoplasm
	Molecular Function	Guanyl-nucleotide Exchange Factor Activity GTPase Activator Activity Protein Binding	Protein Binding Metal Ion Binding Ubiquitin Protein Ligase Activity
	Biological Process	G Protein-coupled Receptor Signaling Pathway Small GTPase Mediated Signal Transduction Positive Regulation Of Apoptotic Process Modulation Of Chemical Synaptic Transmission Regulation Of Small GTPase Mediated Signal Transduction Activation Of GTPase Activity	Protein Ubiquitination Protein Catabolic Process
Pathways		NRAGE signals death through JNK Rho GTPase cycle G alpha (12/13) signalling events	Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS		Age-related cognitive decline (memory) (slope of z-scores) ( 30954325) Heel bone mineral density ( 30598549 28869591) Height ( 28552196) Total cholesterol levels ( 30498476)	Birth weight ( 31043758) Body mass index ( 29273807) Platelet count ( 32888494) Plateletcrit ( 32888494) Schizophrenia ( 25056061 29483656)
Interacting Genes		7 interacting genes: ADRA1A APP ECT2 ERBIN HRAS LNX1 PJA1	64 interacting genes: ABR ASCC2 ATP5F1C ATXN3 ATXN3L CAMK1G CDK16 COASY CSAG3 DDX54 EED ELAC1 ESPL1 EZH2 FGF12 GATD3A GLO1 GSR GTF2I HNRNPC HNRNPL HOMER2 JOSD1 KIF22 LCP2 LRG1 MAGEB4 MAGED1 MDM2 METAP2 NAGK NATD1 NDN OTUB1 OTUB2 PCCA PFKFB4 PHGDH PIP4K2C RIBC2 SPTBN1 STAC STAM STAMBP SUZ12 TAF9 TK1 TMEM214 TSSK3 TXNDC5 UBE2D2 UBE2D3 UBE2E3 UBE2K UBE2L3 UBE2U UCHL3 UCHL5 USP20 USP28 USP5 USP51 USP8 ZNF440
Entrez ID		29	64219
HPRD ID		02649	02335
Ensembl ID		ENSG00000159842	ENSG00000181191
Uniprot IDs		B7Z2X0 B7Z683 B7Z7Z1 Q12979 Q6ZT60	Q8NG27
PDB IDs			2L0B
Enriched GO Terms of Interacting Partners?
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