PJA1 and GLO1

Data Source:
BioGRID (enzymatic study)

		PJA1	GLO1
Description		praja ring finger ubiquitin ligase 1	glyoxalase I
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GO Annotations	Cellular Component	Cytoplasm	Nucleoplasm Cytoplasm Cytosol Plasma Membrane Extracellular Exosome
	Molecular Function	Protein Binding Metal Ion Binding Ubiquitin Protein Ligase Activity	Lactoylglutathione Lyase Activity Protein Binding Zinc Ion Binding
	Biological Process	Protein Ubiquitination Protein Catabolic Process	Carbohydrate Metabolic Process Pyruvate Metabolic Process Regulation Of Transcription By RNA Polymerase II Glutathione Metabolic Process Methylglyoxal Metabolic Process Osteoclast Differentiation Negative Regulation Of Apoptotic Process
Pathways		Antigen processing: Ubiquitination & Proteasome degradation	Pyruvate metabolism
Drugs			Glutathione Indomethacin S-P-Nitrobenzyloxycarbonylglutathione S-(N-hydroxy-N-iodophenylcarbamoyl)glutathione Mercaptoethanol S-benzylglutathione S-Hexylglutathione methyl 4-(2,3-dihydroxy-5-methylphenoxy)-2-hydroxy-6-methylbenzoate
Diseases
GWAS		Birth weight ( 31043758) Body mass index ( 29273807) Platelet count ( 32888494) Plateletcrit ( 32888494) Schizophrenia ( 25056061 29483656)	Blood protein levels ( 30072576) Major depressive disorder ( 29317602) Restless legs syndrome ( 29029846)
Interacting Genes		64 interacting genes: ABR ASCC2 ATP5F1C ATXN3 ATXN3L CAMK1G CDK16 COASY CSAG3 DDX54 EED ELAC1 ESPL1 EZH2 FGF12 GATD3A GLO1 GSR GTF2I HNRNPC HNRNPL HOMER2 JOSD1 KIF22 LCP2 LRG1 MAGEB4 MAGED1 MDM2 METAP2 NAGK NATD1 NDN OTUB1 OTUB2 PCCA PFKFB4 PHGDH PIP4K2C RIBC2 SPTBN1 STAC STAM STAMBP SUZ12 TAF9 TK1 TMEM214 TSSK3 TXNDC5 UBE2D2 UBE2D3 UBE2E3 UBE2K UBE2L3 UBE2U UCHL3 UCHL5 USP20 USP28 USP5 USP51 USP8 ZNF440	4 interacting genes: IKBKG MAP3K13 MEOX2 PJA1
Entrez ID		64219	2739
HPRD ID		02335	00730
Ensembl ID		ENSG00000181191	ENSG00000124767
Uniprot IDs		Q8NG27	Q04760 X5DNM4
PDB IDs		2L0B	1BH5 1FRO 1QIN 1QIP 3VW9 3W0T 3W0U
Enriched GO Terms of Interacting Partners?
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