PJA1 and ESPL1

Data Source:
BioGRID (enzymatic study)

		PJA1	ESPL1
Description		praja ring finger ubiquitin ligase 1	extra spindle pole bodies like 1, separase
Image			No pdb structure
GO Annotations	Cellular Component	Cytoplasm	Nucleus Cytoplasm Centrosome Cytosol Mitotic Spindle
	Molecular Function	Protein Binding Metal Ion Binding Ubiquitin Protein Ligase Activity	Catalytic Activity Cysteine-type Endopeptidase Activity Protein Binding Cysteine-type Peptidase Activity
	Biological Process	Protein Ubiquitination Protein Catabolic Process	Mitotic Sister Chromatid Segregation Meiotic Spindle Organization Mitotic Cytokinesis Proteolysis Apoptotic Process Establishment Of Mitotic Spindle Localization Homologous Chromosome Segregation Positive Regulation Of Mitotic Metaphase/anaphase Transition Negative Regulation Of Sister Chromatid Cohesion Meiotic Chromosome Separation
Pathways		Antigen processing: Ubiquitination & Proteasome degradation	Separation of Sister Chromatids
Drugs
Diseases
GWAS		Birth weight ( 31043758) Body mass index ( 29273807) Platelet count ( 32888494) Plateletcrit ( 32888494) Schizophrenia ( 25056061 29483656)	Femoral neck bone mineral density ( 29499414) Lumbar spine bone mineral density ( 29499414)
Interacting Genes		64 interacting genes: ABR ASCC2 ATP5F1C ATXN3 ATXN3L CAMK1G CDK16 COASY CSAG3 DDX54 EED ELAC1 ESPL1 EZH2 FGF12 GATD3A GLO1 GSR GTF2I HNRNPC HNRNPL HOMER2 JOSD1 KIF22 LCP2 LRG1 MAGEB4 MAGED1 MDM2 METAP2 NAGK NATD1 NDN OTUB1 OTUB2 PCCA PFKFB4 PHGDH PIP4K2C RIBC2 SPTBN1 STAC STAM STAMBP SUZ12 TAF9 TK1 TMEM214 TSSK3 TXNDC5 UBE2D2 UBE2D3 UBE2E3 UBE2K UBE2L3 UBE2U UCHL3 UCHL5 USP20 USP28 USP5 USP51 USP8 ZNF440	7 interacting genes: MTNR1B PJA1 RFFL TRIM55 TRIM63 USP21 USP28
Entrez ID		64219	9700
HPRD ID		02335	06825
Ensembl ID		ENSG00000181191	ENSG00000135476
Uniprot IDs		Q8NG27	Q14674
PDB IDs		2L0B
Enriched GO Terms of Interacting Partners?
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