ABR and ECT2

Data Source:
BioGRID (two hybrid)

		ABR	ECT2
Description		ABR activator of RhoGEF and GTPase	epithelial cell transforming 2
Image		No pdb structure
GO Annotations	Cellular Component	Cytosol Membrane Axon Dendritic Spine Schaffer Collateral - CA1 Synapse Glutamatergic Synapse	Nucleus Nucleoplasm Cytoplasm Cytosol Cell-cell Junction Bicellular Tight Junction Cell Cortex Nuclear Body Midbody Cleavage Furrow Mitotic Spindle Centralspindlin Complex
	Molecular Function	Guanyl-nucleotide Exchange Factor Activity GTPase Activator Activity Protein Binding	Guanyl-nucleotide Exchange Factor Activity GTPase Activator Activity Protein Binding Small GTPase Binding Protein Homodimerization Activity
	Biological Process	G Protein-coupled Receptor Signaling Pathway Small GTPase Mediated Signal Transduction Positive Regulation Of Apoptotic Process Modulation Of Chemical Synaptic Transmission Regulation Of Small GTPase Mediated Signal Transduction Activation Of GTPase Activity	Mitotic Cytokinesis Cell Morphogenesis G Protein-coupled Receptor Signaling Pathway Nervous System Development Protein Transport Cell Differentiation Activation Of Protein Kinase Activity Positive Regulation Of Cytokinesis Intracellular Signal Transduction Positive Regulation Of Protein Import Into Nucleus Positive Regulation Of Apoptotic Process Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of GTPase Activity Positive Regulation Of Neuron Differentiation Regulation Of Protein Kinase Activity Regulation Of Small GTPase Mediated Signal Transduction Protein Homooligomerization Regulation Of Attachment Of Spindle Microtubules To Kinetochore Cellular Response To Hydrogen Peroxide Bicellular Tight Junction Assembly Cellular Response To Calcium Ion Cellular Response To Ionizing Radiation Activation Of GTPase Activity Regulation Of Cytokinesis, Actomyosin Contractile Ring Assembly
Pathways		NRAGE signals death through JNK Rho GTPase cycle G alpha (12/13) signalling events	NRAGE signals death through JNK Rho GTPase cycle G alpha (12/13) signalling events
Drugs
Diseases
GWAS		Age-related cognitive decline (memory) (slope of z-scores) ( 30954325) Heel bone mineral density ( 30598549 28869591) Height ( 28552196) Total cholesterol levels ( 30498476)	Obesity-related traits ( 23251661) Red cell distribution width ( 32888494)
Interacting Genes		7 interacting genes: ADRA1A APP ECT2 ERBIN HRAS LNX1 PJA1	38 interacting genes: ABR C2orf42 CCDC91 CD19 CDK1 CHST10 CSTB EIF4A2 EIF5B ELOC ERAL1 F2RL2 FANCM GGN ILVBL KLHL20 LAMTOR5 MBD1 MT-CO2 MT2A NOMO1 NPC2 OOSP2 OTUB1 PARD6A PCOLCE PLK1 POMP PSMA6 RACGAP1 RHOG RPS20 SNRNP200 SPATA22 SRPK2 THAP11 UBB VDAC2
Entrez ID		29	1894
HPRD ID		02649	11860
Ensembl ID		ENSG00000159842	ENSG00000114346
Uniprot IDs		B7Z2X0 B7Z683 B7Z7Z1 Q12979 Q6ZT60	Q9H8V3
PDB IDs			3L46 4N40 6L30
Enriched GO Terms of Interacting Partners?
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