PJA1 and USP51

Data Source:
BioGRID (enzymatic study)

		PJA1	USP51
Description		praja ring finger ubiquitin ligase 1	ubiquitin specific peptidase 51
Image			No pdb structure
GO Annotations	Cellular Component	Cytoplasm	Chromosome
	Molecular Function	Protein Binding Metal Ion Binding Ubiquitin Protein Ligase Activity	Chromatin Binding Thiol-dependent Ubiquitin-specific Protease Activity Cysteine-type Peptidase Activity Zinc Ion Binding Histone Binding
	Biological Process	Protein Ubiquitination Protein Catabolic Process	DNA Repair Ubiquitin-dependent Protein Catabolic Process Regulation Of Cell Cycle Process Regulation Of Double-strand Break Repair Via Homologous Recombination Histone Deubiquitination Protein Deubiquitination Protein Phosphopantetheinylation Regulation Of Response To DNA Damage Stimulus Regulation Of Double-strand Break Repair Via Nonhomologous End Joining
Pathways		Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS		Birth weight ( 31043758) Body mass index ( 29273807) Platelet count ( 32888494) Plateletcrit ( 32888494) Schizophrenia ( 25056061 29483656)	Educational attainment (years of education) ( 30038396) Mean corpuscular volume ( 29403010) Smoking initiation ( 24665060)
Interacting Genes		64 interacting genes: ABR ASCC2 ATP5F1C ATXN3 ATXN3L CAMK1G CDK16 COASY CSAG3 DDX54 EED ELAC1 ESPL1 EZH2 FGF12 GATD3A GLO1 GSR GTF2I HNRNPC HNRNPL HOMER2 JOSD1 KIF22 LCP2 LRG1 MAGEB4 MAGED1 MDM2 METAP2 NAGK NATD1 NDN OTUB1 OTUB2 PCCA PFKFB4 PHGDH PIP4K2C RIBC2 SPTBN1 STAC STAM STAMBP SUZ12 TAF9 TK1 TMEM214 TSSK3 TXNDC5 UBE2D2 UBE2D3 UBE2E3 UBE2K UBE2L3 UBE2U UCHL3 UCHL5 USP20 USP28 USP5 USP51 USP8 ZNF440	8 interacting genes: H2AC20 H2AC4 H2BC3 PJA1 USP15 USP21 USP28 ZEB1
Entrez ID		64219	158880
HPRD ID		02335	07167
Ensembl ID		ENSG00000181191	ENSG00000247746
Uniprot IDs		Q8NG27	Q70EK9
PDB IDs		2L0B
Enriched GO Terms of Interacting Partners?
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