TDRD7 and MLH3

Data Source:
BioGRID (two hybrid)

		TDRD7	MLH3
Description		tudor domain containing 7	mutL homolog 3
Image			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Mitochondrial Matrix Chromatoid Body Ribonucleoprotein Granule	Synaptonemal Complex Male Germ Cell Nucleus Nucleus Nucleoplasm Chiasma Mismatch Repair Complex
	Molecular Function	MRNA Binding Protein Binding Protein N-terminus Binding	Chromatin Binding Satellite DNA Binding Protein Binding ATP Binding ATPase Activity Centromeric DNA Binding Mismatched DNA Binding
	Biological Process	Lens Morphogenesis In Camera-type Eye Spermatogenesis Posttranscriptional Regulation Of Gene Expression Lens Fiber Cell Differentiation	Mismatch Repair Synaptonemal Complex Assembly Reciprocal Meiotic Recombination Male Meiotic Nuclear Division Female Meiosis I Protein Localization
Pathways			Meiotic recombination
Drugs
Diseases			Mismatch repair deficiency, including: Hereditary non-polyposis colorectal cancer (HNPCC); Lynch syndrome; Muir-Torre syndrome; Turcot syndrome
GWAS		Bisphosphonate-associated atypical femoral fracture ( 31006051) Refractive error ( 32231278) Waist-hip ratio ( 28552196)	Inflammatory bowel disease ( 23128233) Mood instability ( 29187730) Refractive error ( 32231278)
Interacting Genes		20 interacting genes: ATXN2 BUB1 CABLES1 CCND1 CDK17 CDKN2A CTNNA1 DCC DLC1 FRAT1 GABPB1 MAGEA8 MLH1 MLH3 MSH2 MUTYH NRAS ODC1 STK11 TACC1	45 interacting genes: AKT1 ALDOB ANP32B AOPEP AR BAAT CCDC180 CDC14B CDK8 CTSV CYLC2 DVL1 FANCC FBP1 FBP2 FRAT2 GALNT12 HEMGN HRAS HSD17B3 IGFBP3 LEF1 MAP2K1 MLH1 MSANTD3 MSH4 NANS PPP2CB PPP3R2 RASA1 SEC61B SFRP2 SMAD1 STX17 TBC1D2 TDRD7 TGFB1 TMEFF1 TMOD1 TRIM55 TRIM63 TSTD2 XPA ZDHHC17 ZNF510
Entrez ID		23424	27030
HPRD ID		11626	05094
Ensembl ID		ENSG00000196116	ENSG00000119684
Uniprot IDs		Q8NHU6	Q2M1Z1 Q9UHC1
PDB IDs		3RCO
Enriched GO Terms of Interacting Partners?
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