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AP2M1 and HTR6
Data Source:
BioGRID
(two hybrid)
AP2M1
HTR6
Description
adaptor related protein complex 2 subunit mu 1
5-hydroxytryptamine receptor 6
Image
No pdb structure
GO Annotations
Cellular Component
Lysosomal Membrane
Cytosol
Plasma Membrane
Clathrin-coated Pit
AP-2 Adaptor Complex
Endocytic Vesicle Membrane
Clathrin-coated Endocytic Vesicle Membrane
Cytoplasmic Vesicle
Endolysosome Membrane
Intracellular Membrane-bounded Organelle
Clathrin-coated Endocytic Vesicle
Extracellular Exosome
Plasma Membrane
Integral Component Of Plasma Membrane
Cilium
Dendrite
Synapse
Molecular Function
Signal Sequence Binding
Protein Binding
Lipid Binding
Clathrin Adaptor Activity
Ion Channel Binding
Low-density Lipoprotein Particle Receptor Binding
Histamine Receptor Activity
G Protein-coupled Serotonin Receptor Activity
Protein Binding
Neurotransmitter Receptor Activity
Biological Process
Intracellular Protein Transport
Endocytosis
Vesicle Budding From Membrane
Vesicle-mediated Transport
Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II
Receptor Internalization
Low-density Lipoprotein Particle Receptor Catabolic Process
Low-density Lipoprotein Particle Clearance
Cellular Protein-containing Complex Assembly
Ephrin Receptor Signaling Pathway
Regulation Of Defense Response To Virus By Virus
Wnt Signaling Pathway, Planar Cell Polarity Pathway
Membrane Organization
Clathrin-dependent Endocytosis
Regulation Of Vesicle Size
Negative Regulation Of Protein Localization To Plasma Membrane
G Protein-coupled Receptor Signaling Pathway
G Protein-coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger
Chemical Synaptic Transmission
Cerebral Cortex Cell Migration
Positive Regulation Of TOR Signaling
G Protein-coupled Serotonin Receptor Signaling Pathway
Pathways
Nef mediated downregulation of CD28 cell surface expression
Nef Mediated CD4 Down-regulation
Retrograde neurotrophin signalling
Retrograde neurotrophin signalling
Nef Mediated CD8 Down-regulation
Gap junction degradation
Formation of annular gap junctions
MHC class II antigen presentation
EPH-ephrin mediated repulsion of cells
Recycling pathway of L1
Recycling pathway of L1
WNT5A-dependent internalization of FZD4
WNT5A-dependent internalization of FZD2, FZD5 and ROR2
Cargo recognition for clathrin-mediated endocytosis
Clathrin-mediated endocytosis
VLDLR internalisation and degradation
LDL clearance
Potential therapeutics for SARS
Serotonin receptors
G alpha (s) signalling events
ADORA2B mediated anti-inflammatory cytokines production
Drugs
Ziprasidone
Amitriptyline
Olanzapine
Clozapine
Loxapine
Imipramine
Chlorpromazine
Haloperidol
Amoxapine
Paroxetine
Cyclobenzaprine
Ergoloid mesylate
Doxepin
Quetiapine
Aripiprazole
Chlorprothixene
Dimethyltryptamine
Lysergic acid diethylamide
Iloperidone
SGS518
PRX-07034
SUVN-502
Sertindole
Mianserin
Asenapine
Zotepine
Setiptiline
Dihydroergocornine
Gilteritinib
Tiapride
Dihydroergocristine
Aripiprazole lauroxil
Diseases
GWAS
Major depressive disorder (
22472876
)
Chronotype (
26955885
27494321
)
Morning person (
30696823
)
Morning vs. evening chronotype (
26955885
27494321
)
Interacting Genes
76 interacting genes:
ADRA1B
AGTR1
AP2B1
AQP4
ARRB2
ATXN1L
BDKRB2
C1orf35
CACNA1A
CD22
CD3D
CDK11B
CORO7
CSNK2B
CTLA4
CXorf51A
CXorf51B
DAB2
DCX
DPPA2
DVL2
EAF1
EHD2
EIF1AD
FAM90A1
FURIN
FXR2
GAK
GRIN2B
H2BC10
H2BC13
H2BC21
H2BC4
H2BC6
H2BC7
H2BC8
HEXIM2
HTR6
IKZF1
KCNJ11
KNOP1
LAMP1
LTB4R2
LY9
MAB21L3
MED4
MEGF10
MFAP1
MPP1
MTURN
NAA11
NCOR2
NDRG1
NKAPD1
PRPF18
PRPF38A
PRR13
PTS
RALBP1
RNF111
RPL22
RPL38
RRP12
RSPH14
RUNDC3A
SFRP4
STON2
SYNJ1
TASOR
TBC1D5
TGOLN2
TMA16
UBC
UTP25
ZBTB8A
ZNF581
31 interacting genes:
ABCA2
ACTB
AIP
AKR1A1
AP2M1
AP4S1
ATXN10
CHN1
CMSS1
COPS5
DDRGK1
DHRS1
EIF4A3
FYN
GNAQ
GNAS
HDGFL2
IDS
MAP1B
NF1
NRXN3
PARP8
RUNDC3A
SCHIP1
SLC6A1
SRRT
SYT5
THY1
TMEM98
TTYH1
UQCRFS1
Entrez ID
1173
3362
HPRD ID
03014
03066
Ensembl ID
ENSG00000161203
ENSG00000158748
Uniprot IDs
B4DNB9
E9PFW3
Q96CW1
P50406
PDB IDs
1H6E
6BNT
6URI
Enriched GO Terms of Interacting Partners
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Tagcloud
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Tagcloud (Difference)
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Tagcloud (Intersection)
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