HTR6 and EIF4A3

Data Source:
BioGRID (two hybrid)

		HTR6	EIF4A3
Description		5-hydroxytryptamine receptor 6	eukaryotic translation initiation factor 4A3
Image		No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane Cilium Dendrite Synapse	Nucleus Nucleoplasm Nucleolus Cytoplasm Cytosol Membrane Nuclear Speck Dendrite Exon-exon Junction Complex Neuronal Cell Body U2-type Catalytic Step 1 Spliceosome Catalytic Step 2 Spliceosome Glutamatergic Synapse Postsynaptic Cytosol
	Molecular Function	Histamine Receptor Activity G Protein-coupled Serotonin Receptor Activity Protein Binding Neurotransmitter Receptor Activity	RNA Binding RNA Helicase Activity MRNA Binding Protein Binding ATP Binding Poly(A) Binding Selenocysteine Insertion Sequence Binding RNA Stem-loop Binding Ribonucleoprotein Complex Binding Translation Regulator Activity
	Biological Process	G Protein-coupled Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Chemical Synaptic Transmission Cerebral Cortex Cell Migration Positive Regulation Of TOR Signaling G Protein-coupled Serotonin Receptor Signaling Pathway	Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay MRNA Splicing, Via Spliceosome RRNA Processing RNA Export From Nucleus MRNA Export From Nucleus Associative Learning Response To Organic Cyclic Compound Negative Regulation Of Translation MRNA 3'-end Processing Exploration Behavior Positive Regulation Of Translation Embryonic Cranial Skeleton Morphogenesis Cellular Response To Selenite Ion Negative Regulation Of Excitatory Postsynaptic Potential Regulation Of Translation At Postsynapse, Modulating Synaptic Transmission Negative Regulation Of Selenocysteine Incorporation Negative Regulation Of Selenocysteine Insertion Sequence Binding Cellular Response To Brain-derived Neurotrophic Factor Stimulus
Pathways		Serotonin receptors G alpha (s) signalling events ADORA2B mediated anti-inflammatory cytokines production	ISG15 antiviral mechanism Transport of Mature mRNA derived from an Intron-Containing Transcript Deadenylation of mRNA mRNA Splicing - Major Pathway mRNA 3'-end processing RNA Polymerase II Transcription Termination Regulation of expression of SLITs and ROBOs Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)
Drugs		Ziprasidone Amitriptyline Olanzapine Clozapine Loxapine Imipramine Chlorpromazine Haloperidol Amoxapine Paroxetine Cyclobenzaprine Ergoloid mesylate Doxepin Quetiapine Aripiprazole Chlorprothixene Dimethyltryptamine Lysergic acid diethylamide Iloperidone SGS518 PRX-07034 SUVN-502 Sertindole Mianserin Asenapine Zotepine Setiptiline Dihydroergocornine Gilteritinib Tiapride Dihydroergocristine Aripiprazole lauroxil
Diseases
GWAS		Chronotype ( 26955885 27494321) Morning person ( 30696823) Morning vs. evening chronotype ( 26955885 27494321)	High light scatter reticulocyte count ( 32888494 27863252) High light scatter reticulocyte percentage of red cells ( 32888494 27863252) Immature fraction of reticulocytes ( 32888494 27863252) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Myocardial infarction ( 26708285) Reticulocyte count ( 32888494 27863252) Reticulocyte fraction of red cells ( 32888494 27863252)
Interacting Genes		31 interacting genes: ABCA2 ACTB AIP AKR1A1 AP2M1 AP4S1 ATXN10 CHN1 CMSS1 COPS5 DDRGK1 DHRS1 EIF4A3 FYN GNAQ GNAS HDGFL2 IDS MAP1B NF1 NRXN3 PARP8 RUNDC3A SCHIP1 SLC6A1 SRRT SYT5 THY1 TMEM98 TTYH1 UQCRFS1	34 interacting genes: CARD9 CASC3 CCDC174 CDCA7L CNKSR3 CWC22 DDIT4L DDX56 DISC1 DRG2 EHMT2 ERCC6 ESR1 HTR6 LNX1 MAGOH MEOX1 MEOX2 NIF3L1 NXF1 PAX4 PDCD4 PICK1 POLR2G PRMT5 PSMA1 RBM8A REL TRIM27 UPF1 UPF3B VRTN YWHAQ ZXDB
Entrez ID		3362	9775
HPRD ID		03066	06482
Ensembl ID		ENSG00000158748	ENSG00000141543
Uniprot IDs		P50406	A0A024R8W0 I3L3H2 P38919
PDB IDs			2HXY 2HYI 2J0Q 2J0S 2J0U 2XB2 3EX7 4C9B 5MQF 5XJC 5YZG 6ICZ 6QDV 6YVH 7A5P
Enriched GO Terms of Interacting Partners?
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