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AP2M1 and H2BC8
Data Source:
BioGRID
(two hybrid)
AP2M1
H2BC8
Description
adaptor related protein complex 2 subunit mu 1
H2B clustered histone 8
Image
GO Annotations
Cellular Component
Lysosomal Membrane
Cytosol
Plasma Membrane
Clathrin-coated Pit
AP-2 Adaptor Complex
Endocytic Vesicle Membrane
Clathrin-coated Endocytic Vesicle Membrane
Cytoplasmic Vesicle
Endolysosome Membrane
Intracellular Membrane-bounded Organelle
Clathrin-coated Endocytic Vesicle
Extracellular Exosome
Nucleosome
Extracellular Space
Nucleus
Nucleoplasm
Cytosol
Extracellular Exosome
Molecular Function
Signal Sequence Binding
Protein Binding
Lipid Binding
Clathrin Adaptor Activity
Ion Channel Binding
Low-density Lipoprotein Particle Receptor Binding
DNA Binding
Protein Binding
Identical Protein Binding
Protein Heterodimerization Activity
Biological Process
Intracellular Protein Transport
Endocytosis
Vesicle Budding From Membrane
Vesicle-mediated Transport
Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II
Receptor Internalization
Low-density Lipoprotein Particle Receptor Catabolic Process
Low-density Lipoprotein Particle Clearance
Cellular Protein-containing Complex Assembly
Ephrin Receptor Signaling Pathway
Regulation Of Defense Response To Virus By Virus
Wnt Signaling Pathway, Planar Cell Polarity Pathway
Membrane Organization
Clathrin-dependent Endocytosis
Regulation Of Vesicle Size
Negative Regulation Of Protein Localization To Plasma Membrane
Innate Immune Response In Mucosa
Nucleosome Assembly
Protein Ubiquitination
Antibacterial Humoral Response
Defense Response To Gram-positive Bacterium
Antimicrobial Humoral Immune Response Mediated By Antimicrobial Peptide
Pathways
Nef mediated downregulation of CD28 cell surface expression
Nef Mediated CD4 Down-regulation
Retrograde neurotrophin signalling
Retrograde neurotrophin signalling
Nef Mediated CD8 Down-regulation
Gap junction degradation
Formation of annular gap junctions
MHC class II antigen presentation
EPH-ephrin mediated repulsion of cells
Recycling pathway of L1
Recycling pathway of L1
WNT5A-dependent internalization of FZD4
WNT5A-dependent internalization of FZD2, FZD5 and ROR2
Cargo recognition for clathrin-mediated endocytosis
Clathrin-mediated endocytosis
VLDLR internalisation and degradation
LDL clearance
Potential therapeutics for SARS
Recognition and association of DNA glycosylase with site containing an affected pyrimidine
Cleavage of the damaged pyrimidine
Recognition and association of DNA glycosylase with site containing an affected purine
Recognition and association of DNA glycosylase with site containing an affected purine
Cleavage of the damaged purine
Cleavage of the damaged purine
Meiotic synapsis
Packaging Of Telomere Ends
Pre-NOTCH Transcription and Translation
Formation of the beta-catenin:TCF transactivating complex
Formation of the beta-catenin:TCF transactivating complex
PRC2 methylates histones and DNA
Condensation of Prophase Chromosomes
Oxidative Stress Induced Senescence
Senescence-Associated Secretory Phenotype (SASP)
DNA Damage/Telomere Stress Induced Senescence
HDACs deacetylate histones
HATs acetylate histones
HATs acetylate histones
SIRT1 negatively regulates rRNA expression
ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression
NoRC negatively regulates rRNA expression
NoRC negatively regulates rRNA expression
B-WICH complex positively regulates rRNA expression
DNA methylation
Transcriptional regulation by small RNAs
Activation of anterior HOX genes in hindbrain development during early embryogenesis
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3
Ub-specific processing proteases
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks
Nonhomologous End-Joining (NHEJ)
Processing of DNA double-strand break ends
Deposition of new CENPA-containing nucleosomes at the centromere
G2/M DNA damage checkpoint
RNA Polymerase I Promoter Opening
RNA Polymerase I Promoter Escape
E3 ubiquitin ligases ubiquitinate target proteins
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function
RUNX1 regulates transcription of genes involved in differentiation of HSCs
Estrogen-dependent gene expression
Meiotic recombination
HCMV Early Events
HCMV Late Events
Transcriptional regulation of granulopoiesis
Inhibition of DNA recombination at telomere
Amyloid fiber formation
Drugs
Copper
Diseases
GWAS
Major depressive disorder (
22472876
)
Interacting Genes
76 interacting genes:
ADRA1B
AGTR1
AP2B1
AQP4
ARRB2
ATXN1L
BDKRB2
C1orf35
CACNA1A
CD22
CD3D
CDK11B
CORO7
CSNK2B
CTLA4
CXorf51A
CXorf51B
DAB2
DCX
DPPA2
DVL2
EAF1
EHD2
EIF1AD
FAM90A1
FURIN
FXR2
GAK
GRIN2B
H2BC10
H2BC13
H2BC21
H2BC4
H2BC6
H2BC7
H2BC8
HEXIM2
HTR6
IKZF1
KCNJ11
KNOP1
LAMP1
LTB4R2
LY9
MAB21L3
MED4
MEGF10
MFAP1
MPP1
MTURN
NAA11
NCOR2
NDRG1
NKAPD1
PRPF18
PRPF38A
PRR13
PTS
RALBP1
RNF111
RPL22
RPL38
RRP12
RSPH14
RUNDC3A
SFRP4
STON2
SYNJ1
TASOR
TBC1D5
TGOLN2
TMA16
UBC
UTP25
ZBTB8A
ZNF581
7 interacting genes:
AP2M1
ESR1
PTMA
RAD51B
TGM2
UBR2
YWHAQ
Entrez ID
1173
8339
HPRD ID
03014
11897
Ensembl ID
ENSG00000161203
ENSG00000273802
Uniprot IDs
B4DNB9
E9PFW3
Q96CW1
B2R4S9
P62807
PDB IDs
1H6E
6BNT
6URI
5GT0
5KGF
6ACO
6C0W
6FML
6R0C
6RNY
6SE0
6SE6
6SEE
6SEF
6SEG
6UPK
6UPL
6X59
6X5A
6XJD
7A08
7JO9
7JOA
Enriched GO Terms of Interacting Partners
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