AP2M1 and AQP4

Data Source:
HPRD (in vitro)

		AP2M1	AQP4
Description		adaptor related protein complex 2 subunit mu 1	aquaporin 4
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GO Annotations	Cellular Component	Lysosomal Membrane Cytosol Plasma Membrane Clathrin-coated Pit AP-2 Adaptor Complex Endocytic Vesicle Membrane Clathrin-coated Endocytic Vesicle Membrane Cytoplasmic Vesicle Endolysosome Membrane Intracellular Membrane-bounded Organelle Clathrin-coated Endocytic Vesicle Extracellular Exosome	Extracellular Region Cytoplasm Plasma Membrane Integral Component Of Plasma Membrane External Side Of Plasma Membrane Endosome Membrane Integral Component Of Membrane Basolateral Plasma Membrane Sarcolemma Astrocyte End-foot
	Molecular Function	Signal Sequence Binding Protein Binding Lipid Binding Clathrin Adaptor Activity Ion Channel Binding Low-density Lipoprotein Particle Receptor Binding	Protein Binding Water Channel Activity
	Biological Process	Intracellular Protein Transport Endocytosis Vesicle Budding From Membrane Vesicle-mediated Transport Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Receptor Internalization Low-density Lipoprotein Particle Receptor Catabolic Process Low-density Lipoprotein Particle Clearance Cellular Protein-containing Complex Assembly Ephrin Receptor Signaling Pathway Regulation Of Defense Response To Virus By Virus Wnt Signaling Pathway, Planar Cell Polarity Pathway Membrane Organization Clathrin-dependent Endocytosis Regulation Of Vesicle Size Negative Regulation Of Protein Localization To Plasma Membrane	Renal Water Homeostasis Water Transport Cellular Water Homeostasis Water Homeostasis Multicellular Organismal Water Homeostasis Protein Homotetramerization Transmembrane Transport Cellular Response To Interferon-gamma Cerebrospinal Fluid Circulation
Pathways		Nef mediated downregulation of CD28 cell surface expression Nef Mediated CD4 Down-regulation Retrograde neurotrophin signalling Retrograde neurotrophin signalling Nef Mediated CD8 Down-regulation Gap junction degradation Formation of annular gap junctions MHC class II antigen presentation EPH-ephrin mediated repulsion of cells Recycling pathway of L1 Recycling pathway of L1 WNT5A-dependent internalization of FZD4 WNT5A-dependent internalization of FZD2, FZD5 and ROR2 Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis VLDLR internalisation and degradation LDL clearance Potential therapeutics for SARS	Vasopressin regulates renal water homeostasis via Aquaporins Passive transport by Aquaporins
Drugs
Diseases
GWAS		Major depressive disorder ( 22472876)	Blood urea nitrogen levels ( 31152163) Chronic kidney disease ( 31152163) Creatinine levels ( 29403010) Estimated glomerular filtration rate ( 31152163 30604766) Glomerular filtration rate ( 29403010) Metabolite levels ( 23823483)
Interacting Genes		76 interacting genes: ADRA1B AGTR1 AP2B1 AQP4 ARRB2 ATXN1L BDKRB2 C1orf35 CACNA1A CD22 CD3D CDK11B CORO7 CSNK2B CTLA4 CXorf51A CXorf51B DAB2 DCX DPPA2 DVL2 EAF1 EHD2 EIF1AD FAM90A1 FURIN FXR2 GAK GRIN2B H2BC10 H2BC13 H2BC21 H2BC4 H2BC6 H2BC7 H2BC8 HEXIM2 HTR6 IKZF1 KCNJ11 KNOP1 LAMP1 LTB4R2 LY9 MAB21L3 MED4 MEGF10 MFAP1 MPP1 MTURN NAA11 NCOR2 NDRG1 NKAPD1 PRPF18 PRPF38A PRR13 PTS RALBP1 RNF111 RPL22 RPL38 RRP12 RSPH14 RUNDC3A SFRP4 STON2 SYNJ1 TASOR TBC1D5 TGOLN2 TMA16 UBC UTP25 ZBTB8A ZNF581	7 interacting genes: AP2M1 AP3M1 CREB3 CSNK2A1 CSNK2A2 GJA8 HPCAL4
Entrez ID		1173	361
HPRD ID		03014	02631
Ensembl ID		ENSG00000161203	ENSG00000171885
Uniprot IDs		B4DNB9 E9PFW3 Q96CW1	A0A5F9ZHR4 F1DSG4 P55087 V9PBN7
PDB IDs		1H6E 6BNT 6URI	3GD8
Enriched GO Terms of Interacting Partners?
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