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AP2M1 and KCNJ11
Data Source:
HPRD
(in vitro)
AP2M1
KCNJ11
Description
adaptor related protein complex 2 subunit mu 1
potassium inwardly rectifying channel subfamily J member 11
Image
GO Annotations
Cellular Component
Lysosomal Membrane
Cytosol
Plasma Membrane
Clathrin-coated Pit
AP-2 Adaptor Complex
Endocytic Vesicle Membrane
Clathrin-coated Endocytic Vesicle Membrane
Cytoplasmic Vesicle
Endolysosome Membrane
Intracellular Membrane-bounded Organelle
Clathrin-coated Endocytic Vesicle
Extracellular Exosome
Acrosomal Vesicle
Nuclear Envelope
Mitochondrion
Endosome
Endoplasmic Reticulum
Cytosol
Plasma Membrane
Integral Component Of Plasma Membrane
Inward Rectifying Potassium Channel
Intercalated Disc
T-tubule
Axolemma
Neuronal Cell Body
Myelin Sheath
Cell Body Fiber
Molecular Function
Signal Sequence Binding
Protein Binding
Lipid Binding
Clathrin Adaptor Activity
Ion Channel Binding
Low-density Lipoprotein Particle Receptor Binding
Inward Rectifier Potassium Channel Activity
Voltage-gated Potassium Channel Activity
Protein Binding
ATP Binding
Protein C-terminus Binding
ATP-activated Inward Rectifier Potassium Channel Activity
ATPase-coupled Cation Transmembrane Transporter Activity
Ankyrin Binding
Potassium Ion Binding
Heat Shock Protein Binding
Ion Channel Binding
Biological Process
Intracellular Protein Transport
Endocytosis
Vesicle Budding From Membrane
Vesicle-mediated Transport
Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II
Receptor Internalization
Low-density Lipoprotein Particle Receptor Catabolic Process
Low-density Lipoprotein Particle Clearance
Cellular Protein-containing Complex Assembly
Ephrin Receptor Signaling Pathway
Regulation Of Defense Response To Virus By Virus
Wnt Signaling Pathway, Planar Cell Polarity Pathway
Membrane Organization
Clathrin-dependent Endocytosis
Regulation Of Vesicle Size
Negative Regulation Of Protein Localization To Plasma Membrane
Response To Ischemia
Glucose Metabolic Process
Response To Estradiol
Response To ATP
Response To Testosterone
Regulation Of Ion Transmembrane Transport
Regulation Of Membrane Potential
Response To Drug
Negative Regulation Of Insulin Secretion
Regulation Of Insulin Secretion
Nervous System Process
Transmembrane Transport
Cellular Response To Nicotine
Cellular Response To Glucose Stimulus
Cellular Response To Tumor Necrosis Factor
Potassium Ion Transmembrane Transport
Inorganic Cation Transmembrane Transport
Positive Regulation Of Protein Localization To Plasma Membrane
Regulation Of Cardiac Conduction
Potassium Ion Import Across Plasma Membrane
Positive Regulation Of Cation Channel Activity
Pathways
Nef mediated downregulation of CD28 cell surface expression
Nef Mediated CD4 Down-regulation
Retrograde neurotrophin signalling
Retrograde neurotrophin signalling
Nef Mediated CD8 Down-regulation
Gap junction degradation
Formation of annular gap junctions
MHC class II antigen presentation
EPH-ephrin mediated repulsion of cells
Recycling pathway of L1
Recycling pathway of L1
WNT5A-dependent internalization of FZD4
WNT5A-dependent internalization of FZD2, FZD5 and ROR2
Cargo recognition for clathrin-mediated endocytosis
Clathrin-mediated endocytosis
VLDLR internalisation and degradation
LDL clearance
Potential therapeutics for SARS
ATP sensitive Potassium channels
ABC-family proteins mediated transport
Regulation of insulin secretion
Ion homeostasis
Defective ABCC9 causes CMD10, ATFB12 and Cantu syndrome
Defective ABCC8 can cause hypo- and hyper-glycemias
Drugs
Glimepiride
Ibutilide
Verapamil
Tolazamide
Levosimendan
Glyburide
Glyburide
Diazoxide
Thiamylal
Yohimbine
Butamben
Isavuconazole
Diseases
Type II diabetes mellitus
Permanent neonatal diabetes mellitus (PNDM)
Transient neonatal diabetes mellitus (TNDM)
GWAS
Major depressive disorder (
22472876
)
Body mass index (
26426971
28892062
25673413
29273807
)
Circulating leptin levels or type 2 diabetes (
32341051
)
Mean arterial pressure (
27618448
)
Medication use (drugs used in diabetes) (
31015401
)
Pulse pressure (
27618448
30578418
)
Social communication problems (
24564958
)
Systolic blood pressure (
27618448
30578418
)
Systolic blood pressure x alcohol consumption interaction (2df test) (
29912962
)
Type 2 diabetes (
22885922
18372903
24509480
30054458
29358691
30297969
29632382
31118516
32499647
17463246
30718926
17463248
17463249
28869590
19056611
)
Type 2 diabetes (adjusted for BMI) (
29632382
)
Interacting Genes
76 interacting genes:
ADRA1B
AGTR1
AP2B1
AQP4
ARRB2
ATXN1L
BDKRB2
C1orf35
CACNA1A
CD22
CD3D
CDK11B
CORO7
CSNK2B
CTLA4
CXorf51A
CXorf51B
DAB2
DCX
DPPA2
DVL2
EAF1
EHD2
EIF1AD
FAM90A1
FURIN
FXR2
GAK
GRIN2B
H2BC10
H2BC13
H2BC21
H2BC4
H2BC6
H2BC7
H2BC8
HEXIM2
HTR6
IKZF1
KCNJ11
KNOP1
LAMP1
LTB4R2
LY9
MAB21L3
MED4
MEGF10
MFAP1
MPP1
MTURN
NAA11
NCOR2
NDRG1
NKAPD1
PRPF18
PRPF38A
PRR13
PTS
RALBP1
RNF111
RPL22
RPL38
RRP12
RSPH14
RUNDC3A
SFRP4
STON2
SYNJ1
TASOR
TBC1D5
TGOLN2
TMA16
UBC
UTP25
ZBTB8A
ZNF581
7 interacting genes:
ABCC8
ABCC9
AP2M1
EXOSC8
KCNJ2
KCNJ8
LDHA
Entrez ID
1173
3767
HPRD ID
03014
09022
Ensembl ID
ENSG00000161203
ENSG00000187486
Uniprot IDs
B4DNB9
E9PFW3
Q96CW1
B2RC52
Q14654
PDB IDs
1H6E
6BNT
6URI
6C3O
6C3P
Enriched GO Terms of Interacting Partners
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Tagcloud (Difference)
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Tagcloud (Intersection)
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