HTR6 and IDS

Data Source:
BioGRID (two hybrid)

		HTR6	IDS
Description		5-hydroxytryptamine receptor 6	iduronate 2-sulfatase
Image		No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane Cilium Dendrite Synapse	Lysosome Lysosomal Lumen
	Molecular Function	Histamine Receptor Activity G Protein-coupled Serotonin Receptor Activity Protein Binding Neurotransmitter Receptor Activity	Iduronate-2-sulfatase Activity Calcium Ion Binding Sulfuric Ester Hydrolase Activity
	Biological Process	G Protein-coupled Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Chemical Synaptic Transmission Cerebral Cortex Cell Migration Positive Regulation Of TOR Signaling G Protein-coupled Serotonin Receptor Signaling Pathway	Glycosaminoglycan Catabolic Process Chondroitin Sulfate Catabolic Process
Pathways		Serotonin receptors G alpha (s) signalling events ADORA2B mediated anti-inflammatory cytokines production	HS-GAG degradation CS/DS degradation MPS II - Hunter syndrome
Drugs		Ziprasidone Amitriptyline Olanzapine Clozapine Loxapine Imipramine Chlorpromazine Haloperidol Amoxapine Paroxetine Cyclobenzaprine Ergoloid mesylate Doxepin Quetiapine Aripiprazole Chlorprothixene Dimethyltryptamine Lysergic acid diethylamide Iloperidone SGS518 PRX-07034 SUVN-502 Sertindole Mianserin Asenapine Zotepine Setiptiline Dihydroergocornine Gilteritinib Tiapride Dihydroergocristine Aripiprazole lauroxil
Diseases			Mucopolysaccharidosis type II (MPS2); Hunter syndrome
GWAS		Chronotype ( 26955885 27494321) Morning person ( 30696823) Morning vs. evening chronotype ( 26955885 27494321)	Cognitive performance ( 20125193) Idiopathic downbeat nystagmus ( 32157568)
Interacting Genes		31 interacting genes: ABCA2 ACTB AIP AKR1A1 AP2M1 AP4S1 ATXN10 CHN1 CMSS1 COPS5 DDRGK1 DHRS1 EIF4A3 FYN GNAQ GNAS HDGFL2 IDS MAP1B NF1 NRXN3 PARP8 RUNDC3A SCHIP1 SLC6A1 SRRT SYT5 THY1 TMEM98 TTYH1 UQCRFS1	1 interacting genes: HTR6
Entrez ID		3362	3423
HPRD ID		03066	02402
Ensembl ID		ENSG00000158748	ENSG00000010404
Uniprot IDs		P50406	B4DGD7 P22304
PDB IDs			5FQL 6IOZ
Enriched GO Terms of Interacting Partners?
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