WIF1 and RB1CC1

Data Source:
BioGRID (two hybrid)

		WIF1	RB1CC1
Description		WNT inhibitory factor 1	RB1 inducible coiled-coil 1
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GO Annotations	Cellular Component	Extracellular Region Cell Surface	Phagophore Assembly Site Autophagosome Membrane Lysosome Endoplasmic Reticulum Membrane Cytosol Extrinsic Component Of Membrane Nuclear Membrane Phagophore Assembly Site Membrane Atg1/ULK1 Kinase Complex
	Molecular Function	Signaling Receptor Binding Protein Binding Wnt-protein Binding	Protein Binding Protein Kinase Binding Molecular Adaptor Activity
	Biological Process	Signal Transduction Multicellular Organism Development Wnt Signaling Pathway Negative Regulation Of Wnt Signaling Pathway Positive Regulation Of Fat Cell Differentiation Anatomical Structure Development	Autophagosome Assembly Autophagy Of Mitochondrion Liver Development Positive Regulation Of Protein Phosphorylation Autophagy Cell Cycle Heart Development Macroautophagy Regulation Of Macroautophagy Autophagy Of Peroxisome Piecemeal Microautophagy Of The Nucleus Positive Regulation Of Cell Size Positive Regulation Of JNK Cascade Reticulophagy Glycophagy Negative Regulation Of Extrinsic Apoptotic Signaling Pathway
Pathways		TCF dependent signaling in response to WNT Negative regulation of TCF-dependent signaling by WNT ligand antagonists	Macroautophagy
Drugs
Diseases
GWAS		Brain morphology (MOSTest) ( 32665545) Dentate gyrus granule cell layer volume ( 30279459) Dentate gyrus molecular layer volume ( 30279459) Hippocampal fissure volume ( 30279459) Hippocampal subfield CA1 volume ( 30279459) Hippocampal subfield CA1 volume (corrected for total hippocampal volume) ( 30279459) Hippocampal subfield CA3 volume ( 30279459) Hippocampal subfield CA4 volume ( 30279459) Hippocampal volume ( 22504421) Macular thickness ( 30535121) Post bronchodilator FEV1/FVC ratio ( 26634245) Subiculum volume ( 30279459) Total hippocampal volume ( 30279459)	Body size at age 10 ( 32376654) Immunoglobulin light chain (AL) amyloidosis (liver involvement) ( 28679651) Mitochondrial DNA copy number (white blood cells) ( 30704525) Refractive error ( 32231278) Waist circumference adjusted for body mass index ( 28552196)
Interacting Genes		9 interacting genes: AURKA CRADD CYSRT1 FGFR4 ICOS KRTAP10-3 KRTAP10-8 RB1CC1 RPL37	33 interacting genes: AZI2 BAP1 BLID COP1 EPSTI1 ERRFI1 EXOC1 GABARAP GABARAPL1 GABARAPL2 GLCE GREB1 HBP1 IL13RA2 IL24 ITIH5 LYPD3 MADD MRC2 NSD3 PSMC3IP PTK2 PTK2B RNF20 SYN1 TAX1BP1 TBKBP1 THRSP UBC UMPS VHL VPS45 WIF1
Entrez ID		11197	9821
HPRD ID		05541	06019
Ensembl ID		ENSG00000156076	ENSG00000023287
Uniprot IDs		Q9Y5W5	Q8TDY2
PDB IDs		2D3J 2YGN 2YGO 2YGP 2YGQ	6DCE 6GMA
Enriched GO Terms of Interacting Partners?
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