WIF1 and CRADD

Data Source:
BioGRID (two hybrid)

		WIF1	CRADD
Description		WNT inhibitory factor 1	CASP2 and RIPK1 domain containing adaptor with death domain
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GO Annotations	Cellular Component	Extracellular Region Cell Surface	Nucleus Cytoplasm Cytosol
	Molecular Function	Signaling Receptor Binding Protein Binding Wnt-protein Binding	Protease Binding Protein Binding Protein-macromolecule Adaptor Activity Death Domain Binding
	Biological Process	Signal Transduction Multicellular Organism Development Wnt Signaling Pathway Negative Regulation Of Wnt Signaling Pathway Positive Regulation Of Fat Cell Differentiation Anatomical Structure Development	Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Cell Cycle Arrest Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Regulation Of Apoptotic Process Positive Regulation Of Apoptotic Process Cellular Response To Mechanical Stimulus Apoptotic Signaling Pathway Positive Regulation Of Apoptotic Signaling Pathway
Pathways		TCF dependent signaling in response to WNT Negative regulation of TCF-dependent signaling by WNT ligand antagonists	TP53 Regulates Transcription of Caspase Activators and Caspases
Drugs
Diseases
GWAS		Brain morphology (MOSTest) ( 32665545) Dentate gyrus granule cell layer volume ( 30279459) Dentate gyrus molecular layer volume ( 30279459) Hippocampal fissure volume ( 30279459) Hippocampal subfield CA1 volume ( 30279459) Hippocampal subfield CA1 volume (corrected for total hippocampal volume) ( 30279459) Hippocampal subfield CA3 volume ( 30279459) Hippocampal subfield CA4 volume ( 30279459) Hippocampal volume ( 22504421) Macular thickness ( 30535121) Post bronchodilator FEV1/FVC ratio ( 26634245) Subiculum volume ( 30279459) Total hippocampal volume ( 30279459)	Alzheimer's disease (cognitive decline) ( 23535033) Asthma ( 31959851) Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223) Heel bone mineral density ( 30598549 28869591) Height ( 28552196 25282103 31562340 18391951 31217584) High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) Hip circumference adjusted for BMI ( 25673412) Lung function (FVC) ( 30061609 30804560) Pulse pressure ( 27841878) Response to cognitive-behavioural therapy in anxiety disorder ( 31123309) Reticulocyte count ( 32888494)
Interacting Genes		9 interacting genes: AURKA CRADD CYSRT1 FGFR4 ICOS KRTAP10-3 KRTAP10-8 RB1CC1 RPL37	22 interacting genes: ACTN2 APP APPL2 BBS5 CASP2 CASP8 CCSER2 DCXR EEF1A1 ERG28 IL9R KCTD9 KPNA1 LRIF1 PIDD1 PTGER4 RIPK1 SLC35A3 TRIM54 TSHR VTN WIF1
Entrez ID		11197	8738
HPRD ID		05541	04584
Ensembl ID		ENSG00000156076	ENSG00000169372
Uniprot IDs		Q9Y5W5	B4DJT6 F5H7C2 F8VV49 F8VVY5 P78560 Q53XL1 Q8IY43
PDB IDs		2D3J 2YGN 2YGO 2YGP 2YGQ	2O71 2OF5 3CRD
Enriched GO Terms of Interacting Partners?
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