MEI4 and MYO5B

Data Source:
BioGRID (two hybrid)

		MEI4	MYO5B
Description		meiotic double-stranded break formation protein 4	myosin VB
Image		No pdb structure
GO Annotations	Cellular Component	Lateral Element	Cytoplasm Actin Cytoskeleton Myosin Complex Cytoplasmic Vesicle Membrane Vesicle Protein-containing Complex Apical Cortex Recycling Endosome Extracellular Exosome
	Molecular Function	Protein Binding	Microfilament Motor Activity Protein Binding Calmodulin Binding ATP Binding Actin-dependent ATPase Activity Small GTPase Binding Actin Filament Binding
	Biological Process	DNA Recombination Homologous Chromosome Pairing At Meiosis Spermatogenesis Meiotic DNA Double-strand Break Formation Oogenesis	Renal Water Homeostasis Actin Filament Organization Protein Transport Vesicle-mediated Transport Endosomal Transport Vesicle Transport Along Actin Filament
Pathways			Vasopressin regulates renal water homeostasis via Aquaporins
Drugs
Diseases
GWAS		Brain volume in infants (white matter) ( 28763065) Cadmium levels ( 26025379) Macular thickness ( 30535121)	Apolipoprotein A1 levels ( 32203549 29084231) HDL cholesterol levels ( 32203549) Large HDL particle concentration ( 29084231) Mean diameter of HDL particles ( 29084231) Medium HDL particle concentration ( 29084231) Multiple sclerosis ( 31604244) Myopia ( 27182965) Phospholipid levels in large HDL ( 29084231) Phospholipid levels in medium HDL ( 29084231) Refractive error ( 32231278) Resistant hypertension ( 31545351) Spherical equivalent or myopia (age of diagnosis) ( 29808027) Systolic blood pressure x smoking status (current vs non-current) interaction (1df test) ( 29455858) Systolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858) Total cholesterol levels in HDL ( 29084231)
Interacting Genes		36 interacting genes: AFMID BAG4 C19orf25 C1orf109 CABP5 CDKN2D CHAF1A CPNE2 CST9L CTTNBP2 DNTT EIF5A FKBP6 GRB2 HSD3B7 IQGAP1 LGALS14 MACO1 METTL21A MLX MTMR9 MYO5B NGB NME7 OSGIN1 PAFAH1B3 PHYHIPL PLEKHA4 POLR1C R3HDM2 TRAPPC2L TRIM59 TSEN15 TSSK3 USHBP1 VPS26C	20 interacting genes: AMOTL2 BNIP2 COIL CXCR2 EFHC2 FAM214B GMCL1 KIAA1549 MEI4 MEOX2 POLR1C RAB11A RAB11B RAB11FIP2 RAB25 SMAD3 TCF4 TRIM3 TRIM54 ZNHIT1
Entrez ID		101928601	4645
HPRD ID			07582
Ensembl ID		ENSG00000269964	ENSG00000167306
Uniprot IDs		A8MW99	Q7Z7A5 Q9ULV0
PDB IDs			4J5M 4LNZ 4LWZ 4LX0
Enriched GO Terms of Interacting Partners?
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