MYO5B and RAB25

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		MYO5B	RAB25
Description		myosin VB	RAB25, member RAS oncogene family
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GO Annotations	Cellular Component	Cytoplasm Actin Cytoskeleton Myosin Complex Cytoplasmic Vesicle Membrane Vesicle Protein-containing Complex Apical Cortex Recycling Endosome Extracellular Exosome	Endosome Pseudopodium Pseudopodium Membrane Cytoplasmic Vesicle Recycling Endosome Extracellular Exosome
	Molecular Function	Microfilament Motor Activity Protein Binding Calmodulin Binding ATP Binding Actin-dependent ATPase Activity Small GTPase Binding Actin Filament Binding	GTPase Activity Protein Binding GTP Binding Myosin V Binding
	Biological Process	Renal Water Homeostasis Actin Filament Organization Protein Transport Vesicle-mediated Transport Endosomal Transport Vesicle Transport Along Actin Filament	Epithelial Cell Morphogenesis Exocytosis Positive Regulation Of Cell Population Proliferation Positive Regulation Of Epithelial Cell Migration Protein Transport Pseudopodium Organization Regulation Of Vesicle-mediated Transport
Pathways		Vasopressin regulates renal water homeostasis via Aquaporins	RAB geranylgeranylation
Drugs
Diseases
GWAS		Apolipoprotein A1 levels ( 32203549 29084231) HDL cholesterol levels ( 32203549) Large HDL particle concentration ( 29084231) Mean diameter of HDL particles ( 29084231) Medium HDL particle concentration ( 29084231) Multiple sclerosis ( 31604244) Myopia ( 27182965) Phospholipid levels in large HDL ( 29084231) Phospholipid levels in medium HDL ( 29084231) Refractive error ( 32231278) Resistant hypertension ( 31545351) Spherical equivalent or myopia (age of diagnosis) ( 29808027) Systolic blood pressure x smoking status (current vs non-current) interaction (1df test) ( 29455858) Systolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858) Total cholesterol levels in HDL ( 29084231)	Apolipoprotein A1 levels ( 32203549) HDL cholesterol levels ( 32203549) Parkinson's disease ( 32201043)
Interacting Genes		20 interacting genes: AMOTL2 BNIP2 COIL CXCR2 EFHC2 FAM214B GMCL1 KIAA1549 MEI4 MEOX2 POLR1C RAB11A RAB11B RAB11FIP2 RAB25 SMAD3 TCF4 TRIM3 TRIM54 ZNHIT1	14 interacting genes: ACVR1 BMPR1B ITGB1 MED31 MYO5B OPTN RAB11FIP1 RAB11FIP2 RAB11FIP3 RAB11FIP5 SH3BP5L SMAD4 SMURF2 TGFBR1
Entrez ID		4645	57111
HPRD ID		07582	06698
Ensembl ID		ENSG00000167306	ENSG00000132698
Uniprot IDs		Q7Z7A5 Q9ULV0	P57735
PDB IDs		4J5M 4LNZ 4LWZ 4LX0	2OIL 3TSO
Enriched GO Terms of Interacting Partners?
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